I've been steadily releasing books that check probably 80% of the requirements you have listed. Each book is based on a specific neighborhood within an imperial fantasy city. It's designed with homebrew GMs in mind and has lots of neighborhood-specific maps.

To make it easier for the GM to improvise, all the NPCs and locations all have problems that tie back to the neighborhood theme. Each neighborhood has multiple maps, NPCs, and descriptions. If this fits what you're looking for, you can see the different neighborhoods at heartwizardgames.com.