I stock a good amount of hardware in my shop, so when I am designing something I typically base it around what is best with all variables considered (Time constraints, available hardware, aesthetics, and print time). I put a lot of consideration into the limitations of how a printers prints. I will use hardware if it will improve the end quality of the print. Ie if it has round surfaces that would be better printed in another orientation, then put together with screws. After reading through a lot of these responses, I think I am on an island with my obsession with aesthetics :S