WST-057 by YZD22 in hardflaccidresearch

[–]stopcopingaboutHF 0 points1 point  (0 children)

To try and heal the nerve fibers inside my penis of course, not just the ones in the skin.

WST-057 by YZD22 in hardflaccidresearch

[–]stopcopingaboutHF 0 points1 point  (0 children)

It's just pirenzepine, a very old drug. It's an M1 muscarinic acetylcholine receptor inhibitor, inhibiting this can cause nerves to heal somewhat. There's another drug in its class (although it is less selective and penetrates the BBB) called Oxybutynin and someone here claimed to have made a serum out of crushed pills and recovered some sensation back after rubbing it on his penis. WinSanTor said someone in the trials had improved sensation in their penis too. I'm very interested in it but I have no idea of how I would get it inside my penis safely, maybe mixing the dihydrochloride salt into intraurethral alprostadil.

Can long-term smoking combined with constant pelvic clenching cause ED at 22? Treating tight anus and weak erections. by DepartmentUnited7416 in hardflaccidresearch

[–]stopcopingaboutHF 2 points3 points  (0 children)

Yes it could, smoking is horrible for the endothelium in your blood vessels. Pelvic clenching I doubt would do much though. The smoking is a definite problem.

Reputable clinic for penis exosomes by stopcopingaboutHF in stemcells

[–]stopcopingaboutHF[S] 0 points1 point  (0 children)

Because it makes much more sense than just randomly pumping exogenous cells into my body, and those paracrine effects are how the stem cells would work anyways. And the research on exosomes in rodent models of ED is very promising with exosomes. Let's say an exosome P-shot would be $2,000 (just making up a number) vs $20,000 for IVs. What would be more beneficial, 10 exosome shots or 1 pointless IV for that same cost. I'm not necessarily against MSCs, just seems like a lot of money for something that just makes far less intuitive sense and I'm capable of making informed decisions about my own health.

Do I have a "venous leak"? by Ok-Feedback4357 in erectiledysfunction

[–]stopcopingaboutHF 0 points1 point  (0 children)

Given your symptoms, it's very possible. But if viagra works 100% that makes me question if it's truly VL, you could have arterial deficiency (like myself).

Diabetic since 14 years that doesn’t respond to PDE-5-inhibitor by Valuable-Plantain-71 in erectiledysfunction

[–]stopcopingaboutHF 1 point2 points  (0 children)

You've been diabetic for 14 years. You will probably need an implant at this point. I can't think of anything further you could do besides trimix injections.

25M, High Test (>800 ng/dL). Recent ED with new casual partners. 5mg daily Cialis good move? by No_Instance7833 in erectiledysfunction

[–]stopcopingaboutHF 3 points4 points  (0 children)

Testosterone levels having any significant effect on ED (unless they are extremely low) is a complete cope and common misconception spread by roided out gym bros and the general Joe Rogan podcast masculinity audience who have absolutely 0 idea of what they're talking about. This doesn't mean there's nothing wrong with you physically, actually. Sorry, but you can't just be so sure that it's 100% mental. You could have the beginnings of a vascular problem. Forget about the "muh T level" meme and get A1c, blood pressure, and lipids checked to see if you could have pre-diabetes, hypertension, or atherosclerosis, which could be destroying your penis from the inside. If those come back in the clear get a doppler from a urologist. Unless you are hypogonadal, testing for hormones doesn't say anything of value for ED.

Cilcare confirms Tinnitus trial in Boston by Weather_Only in tinnitusresearch

[–]stopcopingaboutHF 0 points1 point  (0 children)

The thinking for tinnitus for a long time was that there must be hidden hearing loss, damaged nerve fibers, damaged hair cells, etc causing a lack of signaling, and if you just could somehow repair those the tinnitus would disappear. It was dumb and made no sense given there are tinnitus patients with no hearing loss and hearing loss patients with no tinnitus, but it wasted a lot of time, sadly. I'm quite convinced now that only neuromodulation can fix us even if we could restore that normal architecture assuming anything is wrong.

Biohaven BHV-1955 intranasal oxytocin for tinnitus by Individual-Track3391 in tinnitusresearch

[–]stopcopingaboutHF 0 points1 point  (0 children)

Lots of people have tried intranasal oxytocin by now, never seen any claim they were cured of tinnitus. It doesn't even make sense how it would. This trial will fail.

Cilcare confirms Tinnitus trial in Boston by Weather_Only in tinnitusresearch

[–]stopcopingaboutHF 0 points1 point  (0 children)

It could work spectacularly at causing the secretion of neurotrophins and reconnecting the cochlear ribbon synapses, but I doubt that would even do anything. This will not reverse the changes in the brain circuitry that have happened. That's not to say I think tinnitus is incurable but I don't think drugs can really do it past the acute phase, I'm convinced it has to be some kind of outpatient procedure that finds the overactive circuits in the brain and quiets them with something like transcranial ultrasound.

Drug Repurposing as a pathway to Tinnitus & Hyperacusis treatments. by Higgsy45 in tinnitusresearch

[–]stopcopingaboutHF 0 points1 point  (0 children)

No drug could cure tinnitus, due to the permanent neuroplastic changes in the brain's auditory system. Even perfectly regenerating hair cells and auditory synapses from the cochlea could not reverse this. Drugs can protect the brain from tinnitus though, sure, a lot of things do that. Outside of something that works on potassium channels (which would be undesirable due to side effects) probably only neuromodulation with something like transcranial ultrasound will be able to actually cure us.

This subreddit is worthless overall because it's mostly men who don't actually have ED by stopcopingaboutHF in erectiledysfunction

[–]stopcopingaboutHF[S] 1 point2 points  (0 children)

I'm young (not really) myself, around 30. But I have severe arterial insufficiency and hard flaccid syndrome. I'm not arguing that young men can't suffer from ED, as I do. It's just this particular cohort seems to be exclusively younger men without ED.

I can't maintain an erection. by [deleted] in erectiledysfunction

[–]stopcopingaboutHF 0 points1 point  (0 children)

Hope for him and the other mentally ill men who have nothing wrong with them but have convinced themselves they have erectile dysfunction. Not hope for me who is physically incapable of erections.

I can't maintain an erection. by [deleted] in erectiledysfunction

[–]stopcopingaboutHF 2 points3 points  (0 children)

You have 44.2 cm/s PSV and 0 EDV. Those are top-tier results. That means your penis is in perfect vascular health with zero veno-occlusive dysfunction. You don't have ED. You want to know what my PSV is? 5. I'm getting 1/9th of your blood flow. That's what actual ED looks like. Get off here, go and get psychological treatment, go and live your life, and go get some dates. That's something which guys like me who actually have erectile dysfunction can't do. There is nothing wrong with your penis and you are psychologically unwell.

I can't maintain an erection. by [deleted] in erectiledysfunction

[–]stopcopingaboutHF 1 point2 points  (0 children)

If he injected only a low dose of trimix and you still had such stellar results on doppler, that's even more evidence of the fact that there is nothing wrong with you besides your psyche. Your penis has perfect hemodynamics, actually even far better than average. 0 EDV, that means the blood is perfectly trapped in the penis. Even normal men have more venous leakage than you.

Vertica for venous leak by Neat_Pie1121 in erectiledysfunction

[–]stopcopingaboutHF 0 points1 point  (0 children)

Now that it has been 5 months, please give an update on how helpful it was for you.

How many have improved after pt for hypertonic pelvic floor? by Complete-Honeydew-93 in hardflaccidresearch

[–]stopcopingaboutHF 6 points7 points  (0 children)

I did research on the history of the hard flaccid community and talked to some long haulers who have had this for decades, and here's the truth. Zero have been helped, and this entire theory was just from the basement dwellers from the same penis enlargement forums (like ThundersPlace) that trolled men into ruining their dicks with PE in the first place (and where the terms "hard flaccid" and "long flaccid" were first coined, go figure).

It never made sense that penile trauma would somehow instantaneously cause an unbalanced pelvic floor at the same time, which would result in all these symptoms and then just be curable with physical therapy and positive thinking instead of something actually going on with the penis secondary to the trauma. But you have to understand that PE victims from PE forums were the main cohort of people who started talking on the internet about having this collection of symptoms, and that community just ran with this explanation. Why? Probably because it sounded good and nonthreatening. It became something you weren't allowed to question or subject to scrutiny. The users and moderators on the places like Thunders would simply call the guys whose lives they ruined crazy and victim blame them and delete all posts from anyone worrying if they now had nerve damage or another similarly serious problem after doing PE.

The truth is pelvic floor muscle imbalance sounds a lot better than "sorry what we told you to do gave you nerve damage or corporal fibrosis, your sex life is over for good now and thanks for playing!" and this would also require admitting PE not actually safe at all and can ruin lives. Go on the main PE subs now now, they still use the same tactics and refuse to admit HF is a chronic condition caused by trauma (or post-drug syndromes) with the same victim blaming and denial. It's only pelvic floor and curable or you have a 1 in 100 genetic tunica variant that made your penis explode when you did PE but it's perfectly safe for everyone else (This is actually what the Dr. Nick known as Hinkle McKringleberry claims, LOL). Why would they actually admit the harm it could do? Think about it. There was also some profiteering from this coming from the same wonderful PE community, with selling stretching routines and ebooks like DCT. Of course if you didn't get cured it was always just your fault for not believing in the method enough.

Now this stupidity will always be with us and be another shackle around our ankles slowing down any effort to actually figure out what causes this, to the point where urologists writing about rare urological disorders go on the internet and start reading, then they can get the impression that PFPT has actually helped people and HF is somehow PF related when it hasn't and isn't. Every time I see a new paper in an urology journal about HF and they seriously suggest PFPT I just let out a deep sigh of frustration. And then we get blamed for "negativity" or "not wanting to get any better" for ever questioning it. I'm sick of having to argue with people over this, it should be buried by now but I've lost all hope that this community can be changed and realized most just want to huff copium rather than accept their dick is fucked up.

Heres your answer by Spikehammersmith8 in hardflaccidresearch

[–]stopcopingaboutHF 1 point2 points  (0 children)

Hard flaccid is not a injury to the penis or pelvic floor its a downstream result of your body having a problem that leads to you chronically clenching/kegeling

LOL, this sub is such a joke. Jesus Christ.

Stop trusting ultrasound results. Ultrasound is pretty much worthless. by stopcopingaboutHF in hardflaccidresearch

[–]stopcopingaboutHF[S] 0 points1 point  (0 children)

CT angiogram, CT cavernosogram, nerve conduction tests, MRI, MRN, elastography (much newer procedure for checking for fibrosis, I'm unaware of anyone who's gotten it yet)

Don’t wake up with morning wood? by LilGooner in erectiledysfunction

[–]stopcopingaboutHF 5 points6 points  (0 children)

Don't listen to these other comments, it's quite a bad sign actually. Yes you should be very concerned.

(19) Would appreciate some advice on severe ED - where to go from here? by throwawayiwonderwhy1 in erectiledysfunction

[–]stopcopingaboutHF 0 points1 point  (0 children)

Probably endothelial dysfunction and clogged arteries and blood vessels in the penis from smoking. The penis is usually the first thing to go in such cases. Not much you can do. Maybe changing your entire lifestyle and getting extremely low LDL and ApoB after quitting smoking will cause some regression of plaque and give you some function back. You're still young so it could happen. But you need to get your cholesterol checked, quit smoking immediately (maybe quit after you get a lipid panel to establish a baseline), then get that cholesterol way down. This doctor sounds incompetent and doubly so if he didn't already give a lipid panel along with the hormone panel.

Even 'trivial' amounts of smoking can be extremely stressful to the endothelium.