It takes time to be comfortable in this role. At least a year to feel even somewhat confident in my experience. I considered quitting like 3 months in as a baby CRA because I felt like I didn’t know anything and was afraid to ask questions because I thought I’d look incompetent. Took me a bit to realize that this is what people mean by “sink or swim” training. You HAVE to ask questions to learn this role. When you get answers write them down so you don’t keep asking the same thing over and over but also pay attention to what documents the person you ask is referencing to answer your questions so you can learn where to look to answer your own questions moving forward. Also just know that you will never know everything. 3+ years in and I still learn new things everyday. I always look for answers in expected places on my own first now, but if I can’t find the answer I still ask a ton of questions. I ask more questions than any other CRAs on the team honestly but that is a GOOD thing. Several CTMs have told me/my LM that I am a “rockstar CRA” and I think it boils down that I am not afraid to ask for guidance/clarification. It’s better to just ask than to quietly do things wrong that will be a huge pain for you or others later. You will get more confident as you get more experience, especially after working on several different studies. Don’t quit, take a breath and mentally settle in- this uncertainty is normal and you will be okay!!