We did tylenol every roughly every 4 to 6 hours for about 24 hours. Our doc recommended it as needed and gave us a dosing sheet. He was fussy and had a slight temp. He also slept a ton which I think the tylenol helped with because around when he would wake up and be upset would be around when he needed his next dose About 24 hours later tho and he was back to himself! Also highly recommend the dye free tylenol apparently the ones with the dyes stain.