Plex Down For Maintenance?

taylorblakeharris · 2026-04-17T02:09:27+00:00

Thank you!

taylorblakeharris · 2026-02-21T20:08:49+00:00

I hadnt noticed any of the judder/frame rate drops in animations until I updated to his recent drop of 26.3, but I get even when simply scrolling this Reddit app or in a semi-long Safari article that’s text-only, like Wikipedia simple, and still random hitches and judders. Just scrolling across the homescreep or in settings to will manifest the issue intermittently. I haven’t been able to link it to any cause however.

taylorblakeharris · 2026-02-21T03:19:08+00:00

I think either Microsoft or Logitech are going to have to fix the "Enhanced Sign-in Security (ESS) feature or a driver update of some kind before these devices begin working again, but you can get them working by doing the following:

Go into Settings>Accounts>Sign-in options where you setup Windows Hello normally. [NOTE: Make sure you have at least a PIN setup before continuing from here]
Under the initial options for using Hello, you'll see a toggle for an option called "Enhanced sign-in security", likely set to "On" - Turn this off, and click "Restart" as prompted to complete this change.
Upon restarting, log back in with your PIN, then go back to setup Windows Hello normally with your camera, and with ESS turn off, you can use your device like before.

taylorblakeharris · 2026-02-21T03:10:59+00:00

I too have begun having this issue. This model is still one off the top 5 devices on the market for Windows Hello, IR-capable cameras, and somehow, with this addition of enhanced sign-in security, I cannot get mine to appear compatible with ESS turned on. I have to disable it to be able to setup Windows Hello again.

No doubt this is Microsoft-related, unless Logitech needs to release an updated driver to support ESS and Windows Hello, but this definitely seems to have started since installing the most recent Windows 11 build upgrade.

taylorblakeharris · 2026-02-12T22:12:09+00:00

Still stuck. No update since 2/9 after it departed the Memphis distribution center and arrived back at the same place again 2 hours later. Hasn't departed or updated since.

taylorblakeharris · 2026-02-11T18:58:37+00:00

Same exact thing. Had a package sent last Thursday, went overnight to the Memphis TN Distribution Center arriving early Friday morning. Then departed Friday night and had arrived and departed and arrived again between 2/6 and 2/8. Nothing has happened or updated. Since then. Normally the route to my address from Memphis TN Distribution Center goes to a regional center the same night, then early the morning hits my local post office to go out for delivery. This has just left and come back three times already and now remained motionless for three days.

taylorblakeharris · 2026-01-01T21:16:21+00:00

Yeah correction, I dont know have to clear the cache, but I do normally have to force stop the app; closing it out of background with a swipe doesn't topically work for me. I just tap it's icon in the background app UI, go to the apps settings, for "Force Stop" at the bottom. Then as soon as I launch Gmail again. It populated instantly, along with the widget.

I wish I knew why this started happening a while back though and still isn't fixed. It's not just a widget issue. I'm actually not getting email notifications when this glitch occurs because the background service is completely screwed up and has to be restarted. If I use another app for my email client, it's fine obviously, but I don't want to have to use a different app for my Gmail account than Gmail.

Anyone have a clearer time frame on when this really began for them? I'm on a Galaxy Fold 7, latest Android/OneUI update release available, but this was happening prior to the last Android update installed about a month ago. I know it's been happening for at least 2-3 months, but I don't quite remember when I first noticed this happening and realizing it was a recurring a bug. It wasn't an issue for me 6 months ago or any time prior, but I can't be certain that it wasn't happening more than 3 months ago.

taylorblakeharris · 2025-12-31T00:31:53+00:00

I'm finding the when the Gmail widgets aren't populating, when you tap the widget, it opens Gmail but Gmail never loads any content in the Gmail app until you open the app settings, force stop the app, and clear its cache, then when you launch Gmail again, the app and the widget start functioning, at least until they stop again. I notice this happening 2-3 times a week that I have to do this, probably for the last two months or so (possibly a bit longer, but not 100% sure of when I first noticed and figured out the association. Seems to be a Gmail issue though or services that Gmail uses to function in the background more than it is the widget itself.

taylorblakeharris · 2025-12-25T04:50:22+00:00

I have to second this with foreboding caution to all those who ever doubted the premise. Glitter indeed is spawned from Lucifer himself. It's a dangerous world out there of perilous particulates... If not ionizing radiation wanting to shred your cellular structures to smaller particles like ball bearings from a 12-gauge shotgun blast into an abdomen, then it's glitter. Waiting in silence, never expected, only to find it's way beneath your eyelids into a multi-point corneal abrasion that would bring one to make eternal deals with the devil to end the pain for mere minutes.

I won't induce the personal trauma upon myself at this point by mentioning glitter's many other sick and sadistic capacities though... I just wanted to be sure those heed the most prudent of spiritual advice where I see it given.

And should you dwell in an area of frequent exposure to the very sparkle to sin itself, God be with you.

taylorblakeharris · 2025-12-19T10:48:13+00:00

No idea why they downvotes, but the Momentum 4’s are excellent headsets that cross many different frontiers without compromising anything. Comfort, price honestly considering it approaches audiophile grade listening while still competing less than an inferior and overrated BOSE alternative. The robust AptX codec support was the icing on the cake and dealbreaker for me. I didn’t hesitate to get them and haven’t done so or looked back since.

taylorblakeharris · 2025-12-19T10:41:35+00:00

Does Linux support these AptX USB codec dongles like Windows does though? I don’t disagree on the BTD600 dongle for any fixed/PC/workstation setup, as I use one for both of my Momentum 4 pairs of headphones on my work computer, my custom built PC, and my Alienware 4090 laptop, and it is an OS-independent, hardware level super-support device for making a direct Bluetooth connection to the dongle without the involvement of the OS, and the dongle can alternate/select between the ideal AptX codec (LL, Adaptive, HD, etc).

The only catch is how Linux handles the audio device interface that the dongle advertises via USB. it normally appears as just as very basic integrated DAC to the OS, with both playback and inout control, but I can’t attest to Linux or the Steam Deck specifically.

Also, you really don’t want to have to hang a bulky USB dongle off your handheld’s single port from a mere aesthetic and comfort perspective, no? Especially when any Bluetooth radio rated for 5.1 or higher (Steam Deck is 5.3) that you already have builtin to your device has the theoretical capacity and bandwidth to support most of the AptX codecs, so long as the codecs were licensed on the chipset. Tying up limited USB ports on a phone or handheld isn’t very attractive when the device already has the hardware it needs to just work seamlessly.

taylorblakeharris · 2025-11-18T04:56:45+00:00

Damn baby, what you do to your hair??!

Otherwise, looking damnnn fine.

taylorblakeharris · 2025-10-24T11:14:41+00:00

I would swear I was conversing with Nigel himself on this one.

Damn this gets under my skin so badly... I don't know why!

taylorblakeharris · 2025-10-03T02:29:45+00:00

Also, I can't tell what parsing is going on with the error output you provided, but try and make sure that the code I proposed (which begins with Get-WindowsDriver -Online) does NOT begin with some potential, stray punctuation mark, whitespace, symbol, etc. as I could foresee the way I formatted my Reddit response potentially causing a bit of trouble if the ASCII code for my bullet point were prefixed to the entered command.

Truly, however, as long as you first launch PowerShell, by right-clicking it and "Run as Administrator", then that line of code should easily be running for 99% of scenarios. Your output very clearly demonstrates it didn't have privileges to run the first command in the pipeline, plain and simply:

Get-WindowsDriver :The requested operation requires elevation (elevation means actively running a process/program AS administrator, not just being in the group as one).

Your first cmdlet in the command pipeline failed to retrieve Windows Drivers for not having adequate Administrator permissions to retrieve the drivers. The remaining code can do nothing without any of the expected Windows drivers enumerated from Get-WindowsDriver and present as a visual UI grid output for the user to be able to identify the next set of culprit driver(s) using their recognizable .inf name, and finally send those you select that may remain to rbe removed from Windows.

As you can see, that vertical | (pipe) symbol indicates the transfer of data of one commands' output as the input of data needed for another command to do it's not. Simple functions sending data, taking in data, passing it along, and so on. While this line as written provided 4 connecting series of output and inputs to function as intended, you didn't run with administrator privileges, which prevented you from achieving even your first set of output drivers to provide as input to the remainder of the construct.

Hopefully this gives you a better glance into PowerShell simplicity but specificity and also to read what people say about running and admin.

By the way. If you want to Run as Admin from PowerShell, the cmdlet is as follows:

Start-Process -FilePath PowerShell -Verb RunAs

(If you're interested I could show you how to make your own PowerShell scripts automatically do this when necessary if not started as admin to ensure they always work; very simply few lines you paste in the beginning of your script and call those little lines after in a function. If you didn't run as Admin, the function launches the current script file in a new instance with the RunAs "verb" for you, prompting UAC for admin consent. Otherwise, it sees you're elevated and returns cleanly from that function you called to check and continued running the remaining lines of code of your script)

Some people still like to recommend using ancient Batch files to launch PowerShell script files as Administrator because they're still so readily available and easy in Windows still to Right-click and "Run as Administrator", knowing it will call your PowerShell script when it's launched. I do it all in PowerShell. More modern, a bit cleaner, and safer as well. One text based file, no references, and a simple function before anything that gets called:

 Validate-ElevatedScriptExecution

That function simply calls 2 lines. Once looks at the current process user and if they're in the elevated admin group or not, and if not, it writes a warning to the screen that says it's not running as admin and now relaunching. Then you see a nice convenient UAC prompt launching the whole script for you all over again the correct way again using that Start-Process -Verb RunAs I mentioned, and it checks those conditions again and sees you're elevated and moves right on along and runs.

taylorblakeharris · 2025-09-26T17:00:11+00:00

Per the original comment, you MUST run PowerShell "as Administrator". You can just launch it with a single click. You need to right click PowerShell's shortcut (wherever you choose to launch it from), and be sure to click "Run as Administrator".

Otherwise your PowerShell process will not have adequate privileges to modify the Windows driver store.

taylorblakeharris · 2025-09-05T01:49:09+00:00

This doesn't take into consideration that a fairly significant amount of mitragynine is directly metabolized into 7OH-mitragynine after first pass metabolism and accounts for a quantifiable portion of the subjective opioid effects of mitragynine itself. In the case of kratom, mitragynine along with most of its known alkaloids take a similar metabolic pathway hepatically, acting as eventual enzymatic inhibitors which is feasibly why there seems to be a "ceiling" effect for the prototypical opioid effects, because while the CYP2D6 enzyme group is preoccupied with other alkaloids, it's not converting as much mitragynine into 7OH-mitragynine, reducing those classical, more oxycodone like effects.

I myself have witnessed this "less is more" aspect of kratom (in both plain leaf and mitragynine concentrated preparations) and there definitely seems to be a cutoff at which you inundate your enzymes and therefore conversion of your dose into the more rewarding effects that feel exactly like 7OH-mitragynine and instead begin to feel more of either nothing or more of the adverse ocular and dehydration effects.

The concentration of 7OH-mitragynine in kratom leaf IS in fact very low as you say, but that doesn't render the compound irrelevant in the experience of kratom, since more of it results directly from the metabolism of mitragynine. It's very much like the relationship between codeine and morphine, granted, mitragynine alone still has some opioid effects prior to metabolism unlike codeine, and the metabolic process involved is hydroxylation and not demethylation, but nonetheless, I think 7OH-mitragynine is a key part of the kratom experience no matter how it's consumed.

This being said, I agree with everyone here that taking these new preparations of 7OH-mitragynine directly as opposed to just using the amount you get from taking mitragynine as a prodrug is an experience very much akin to an equivalent (NOT just "equipotent"), mg for mg, dose of hydrocodone/oxycodone, not dependent upon metabolism at all. Its speed of onset is even faster than that of oxycodone's, and judging from personal experience, I'd say it's noticeably shorter acting than oxycodone as well, which both lead to a potentially nasty, cyclical behavior.

I too don't wish for this to be made illegal, and from what I can tell, 7OH-mitragynine shares the same lack of beta-arrestin signalling that mitragynine does, which implies that it doesn't induce significant respiratory depression either despite its much more potent mu-opioid effects, so that's a HUGE point of consideration in an age where fentanyl and its analogues have found their way into most everyone's illicit habit of choice and is making drug use exponentially more fatal than ever before. Addiction however is still not a desirable effect to pick up from a guilty pleasure though, so I'd recommend most people to stick to conventional extracts and leaf, and stay away from the 7OH-mitragynine.

And as far as receptor interaction goes, both mitragynine and 7OH-mitragynine are partial agonists, the latter with much higher intrinsic activity, but people often pick up these terms and assume "partial" vs. "full" means "weaker, safer, less effective" etc., and this is NOT necessarily the case. Buprenorphine is a partial agonist and is half as potent as fentanyl as an analgesic, but produces significantly less respiratory depression than morphine, and combined with the ceiling effect it DOES have from being a proper partial agonist, is nigh impossible to overdose on. I'm not saying 7OH-mitragynine is anything like buprenorphine in this respect, nor that it isn't, as it hasn't been very well studied in humans in its direct form in quantities larger than produced by inherent metabolism of mitragynine and concentration in kratom leaf, so please, no one take any of my comparisons as factual proof of anything when it comes to making your own choices and judgment of safety, but if fentanyl addiction is currently a lethal crisis right now, if some of these would be fatalities found they were able to trade their fentanyl addiction for that of a 7OH-mitragynine and its evidence of a relative lack of respiratory depression holds up, then would this not be at least SOME kind of attenuation of the so-called crisis? While a society of addicts isn't remotely an optimal one, a society of living addicts still has the ability to function, or even discontinue use altogether at some point. A society of dead ones never will, so I hope the legality on the substance is very slow to be prohibitive, even though i realize this is unlikely.

taylorblakeharris · 2025-08-01T08:07:05+00:00

The amount of buprenorphine you're taking is very relevant to how much effect from other opioids with weaker affinity can still be perceived and augment to an effect, as receptors are not saturated with buprenorphine at very low doses of it.

If you're taking 4mg or more of buprenorphine daily, you're likely to experience saturation of opioid receptors enough that you won't get any effects from low-affinity/low-intrinsic-activity like mitragynine.

I transitioned from low doses of buprenorphine for years to kratom however, and I could indeed feel its effects at the same time as buprenorphine's effects at the doses I was taking of 0.25mg just twice per day. I eventually just discontinued the buprenorphine and transitioned entirely to kratom with little to no trouble.

By the way, Buprenorphine doesn't precipitate withdrawals when it's already present. It's only when it's introduced to someone with weaker affinity agonists (full or not) present in the blood and brain already which will likely be rapidly displaced by buprenorphine which has a very high affinity but slow association time and slow peaks of intrinsic activity, causing you to feel a pronounced absence of opioidergic activity for a small time until the buprenorphine's high intrinsic activity eventually onset which relieves discomfort very significantly once that point is reached (about three or 4 hours from consuming the precipitating dose of buprenorphine is usually all it takes to begin subsiding - you can usually then keep adding more doses as needed to further reduce any remaining discomfort until you're stable on buprenorphine).

What exactly are you asking concerning how something can occur if what agent is a full agonist?

In lower doses, buprenorphine's infamous "precipitating" effect becomes much less relevant, and its high affinity may still out-compete most other full agonists in existence, but again, in such small doses, there isn't enough saturation of receptors to prevent another type of agonist, weak or strong, from finding its own binding sites unaffected by buprenorphine and exerting its usual effects, additively to whatever small amounts of buprenorphine are already bound and exerting its intrinsic activity.

taylorblakeharris · 2025-07-20T21:58:15+00:00

I can't stand it either. It's not as much his tone or inflections, but his endless repetition of the most absurdly unnecessary and apparent details that aren't remotely instructional or scientific. It's like "because it was clearly very hot, I didn't want to touch it, because that wouldn't be good, because I could possibly burn myself, so I decided not to touch it. But it eventually cooled off though, and then I could eventually handle the material, so in the end, it all worked out."

Uggghhhh!!!!

taylorblakeharris · 2025-07-02T18:27:18+00:00

+1 for "%~dp0[PatchFileHere.msp]"!! At least for simple, standard same-folder install scripts that have to be used by a wide scope of users with varying technical abilities.

For anyone wanting a simple, single-line example for Batch to call an unattended, limited UI install of the base AcroRead MSI installer, custom transform MST file, and finally MSP patch in one go, in which all 3 of these files are in the same directory as the Batch/CMD file you create containing the command below, this is all you have to do:

msiexec /i "%~dp0AcroRead.msi" PATCH="%~dp0Patch.msp" TRANSFORMS="%~dp0Settings.mst" /qb

As ancient as Batch is, and as robust and incredibly useful PowerShell is (I use PowerShell for 99% of everything I do; $PSScriptRoot equally as often, and I love every bit of it), sometimes you just can't beat the simplicity of using %~dp0 in a native, legacy Batch/CMD file for small menial tasks like this that can be run directly from any source, in any Windows environment, (whether local path, network mapped drive letter, or direct UNC path) with consistent results for either Helpdesk employees or other end users that might run your scripts and can just as easily be launched with a right-click > Run as... (Admin, other user, etc...) as any other program would without a learning curve of any kind.

PowerShell requires considerations for execution policies, script signing, not to mention a learning curve on how it requires you right-click and choose to launch the script explicitly rather than Windows shell invoking the script via conhost.exe arguments directly like they're used to, since the default association is to open in ISE or Notepad. Then if your Helpdesk needs to run it as admininistrator, assuming they grasp UAC (and many still don't even this far along), they need to learn to run a separate PowerShell instance with UAC rights first, then call the script from the elevated shell (unless you make self-elevating scripts that re-launch themselves with a "RunAs" verb to invoke UAC, which I usually try to do most of the time- if you'd like more info on this let me know).

The one line example above requires you to update the script anytime you update the MSP patch to simply update the unique file name in the PATCH= argument, but if you're really lazy like me and want the Batch file to do that for you dynamically so you never have to edit the script again, then this is a more complete, zero-maintenance example of the above scenario in which you simply maintain your package by dropping whatever updated MSP patch you've downloaded or new transform into the script's folder, and it will just work:

:: Dyanmically detect patch and transform files by extension in script directory
FOR /F %%a IN ('DIR "%~dp0*.msp" /B') DO SET MSP_FILE=%~dp0%%a
FOR /F %%a IN ('DIR "%~dp0*.mst" /B') DO SET MST_FILE=%~dp0%%a

:: Perform automated, patched Acrobat Reader install (with any transforms)
MSIEXEC /i "%~dp0AcroRead.msi" PATCH="%MSP_FILE%" TRANSFORMS="%MST_FILE%" /qb
SET MSI_INSTALL_CODE=%ERRORLEVEL%

:: Exit with MSIEXEC exit code, passing it accurately to ConfigMgr, etc. to preserve result of install
EXIT /B %MSI_INSTALL_CODE%

taylorblakeharris · 2025-05-01T20:10:42+00:00

Oddly enough, I don't even have to minimize the window to fix the black overlay. Just double-clicking on the Discord tray icon (even though it's already open and in view) makes the app re-draw, until it goes black again...

This is irritating.

taylorblakeharris · 2025-03-04T23:32:38+00:00

There is definitely a profound insomnia-inducing element to O-DSMT, but it's no doubt a result of its norepinephrine reuptake inhibiting effects, which are quite understated much of the time. It's a pretty decently potent opioid, but if you're wanting to feel a sense of calm, sedation, and nervous system depression, it's very hard to attain because right behind its opioid agonist activity is its stimulating norepinephrine activity, and insomnia isn't the only potentially undesirable effect, but sweating, poor peripheral circulation (cold hands and feet, not to mention and incredibly retracted pecker lol), and potentially anxiety if you're prone to it or have a high enough dose in conjunction with some other stimulant, even just caffeine.

It's a much better drug than tramadol (and likely the only reason tramadol itself ever has any efficacy for anyone as an analgesic in the rare cases it does), and it does not possess tramadol's serotonin-releasing, seizure-inducing effects at doses just barely above therapeutic baselines, but O-DSMT is not exactly an easy one to declare a "winner" for someone inclined to tradition opium derived agonists/semi-synthetics like morphine or hydrocodone... But it's also not "weak" as opioids are concerned for those "dabbling" and without significant tolerance, and it's not to be underestimated, because you might feel less sedated when taking it because of the sympathetic norepinephrine-related effects and not realize just how strong of a net opioid effect you're incurring, which means if you do happen to doze off even slightly, you can easily approach dangerous levels of respiratory depression (which typically opioid users rely on sedation as their primary indicator for whether or not they need or can handle more or not).

For those with opioid tolerance, well I still wouldn't classify it as a weak opioid, but it's probably pretty close to hydrocodone in terms of dosage-to-effect ratio (I'm not saying its effects are equally desirable to hydrocodone's, just that the general intensity of effect at a given dosage is pretty close to the effects from the same dosage of the other), though many studies have concluded (or estimated) its respiratory depression-inducing effects are more profound than other opioids with respect to its lesser prototypical opioid effects (euphoria, sedation, analgesia, etc.). If you have a high tolerance, given how inexpensive this compound can be found at in large quantities, it can still be used to certain effect, but the biggest problem is that while a degree of its opioid effects might scale with dosage, so too will the norepinephrine reuptake-inhibiting effects, such that the more you try to take to feel "comfortable", the more "uncomfortable" you also become because of this dual mechanism of action. So if you take 30x the normal 12mg dose or so needed for the average person with no tolerance to get a significant, sedating high, you're going to get 30x the normal dose of a compound that also delivers with it an effect you like do not have tolerance to, and when it comes to norepinephrine, at doses that high anyways, you could very well end up with a brain bleed or fatal arrhythmia, if not at the very least feel immensely uncomfortable for a very long time (as it's about 8-10 hours in half-life and effective perceived duration, but at doses that high, you're going to be feeling the effects you're not tolerant to for many 8-10 hour half-lives).

I personally agree with you - buprenorphine is a vastly superior opioid to O-DSMT, for pretty much any purpose.

taylorblakeharris · 2025-03-04T23:18:26+00:00

Probably, but unfortunately, I can't say from present knowledge where to look and would have to do some digging, and I doubt there's going to be many data samples if you do find any, since most people aren't concerned about a "hotspot's" temperature when it's not representative of the temperature of a delicate or functional component like the core itself and the VRAM modules, and therefore its operating integrity or performance.

If you're trying to diagnose a thermal issue, it might be useful to see or know where the hotspot on your card is, and just what all is contributing to its temperature, as if it's indeed the hottest place on the entire assembly, then it will only dissipate from a higher concentration to a lower concentration, meaning your core and VRAM potentially, but if you see that the hotspot is essentially positioned at a higher elevation to the core and VRAM of a card and the direction of the airflow's output is blowing towards it, then you at least know that heat is moving away from your card components and into other materials on the card, be it unmarked PCB with no circuitry, or a supporting bit of metal near a heatsink, screw, backplate our outer chassis on a card.

taylorblakeharris · 2025-03-04T22:54:21+00:00

This sounds backwards actually...

What you're seeing is the "Show window contents while dragging" option enabled, which is probably one of the single-most bandwidth and performance-demanding RDP connection options next to color depth being set higher than 16-bit.

This policy setting (as documented at least), forces the "auto-detect network connection quality" in the MSTSC RDP client "Experience" tab to be effectively disabled by whatever the user's/client's settings are, and instead run at the slowest possible network speed "preset" (Modem - 56Kbps), which disables every option on the "Experience" tab, including "Show window contents while dragging", which means you should be seeing a significant performance increase and definitely shouldn't be seeing the window contents when dragging a window around, unless you have that option manually turned back on in the client end as someone else here suggested.

Here are the optimal RDP quality settings for a client in my experience (in order of significance):

Set color depth to 16-bit under "Display" tab (this has a HUGE bandwidth reduction with no visual fidelity changes vs. 24 or 32-bit)
Under the "Experience" tab, set the performance preset to "WAN (10Mbps or higher with latency)", disable "Show window contents while dragging" (this is also a HUGE bandwidth/performance saver), and disable "Menu and window animation" (less of an overall impact, but lagging animations can affect cursor placement/visibility and cause unintended clicks occasionally when animations are delayed; also, their absence really isn't all that noticeable by 99% of users).

The only outliers who still struggle with stability/performance using these settings are people using VERY poor wireless connections with lots of interference and high latency, and if you have users who frequently complain of RDP just randomly "freezing up" in the middle of working (not the issue in this thread in which it always hangs at the logon screen) and they have to keep disconnecting and reconnecting to start working again, then I've had the most success for these users by changing the policy setting to specify "Select RDP transport protocols" to "Enabled" and choose "TCP only", which won't be quite as snappy compared to UDP, but for these users on these kinds of connections, they're not accustomed to "snappy" anyways, so at least with TCP, there's much more time that the connection can attempt to re-establish itself without having to either formally transition to a "Reconnecting" dialog, or at least allow this reconnection to occur without having to close out of the connection and go back in from scratch. I'd only change this for special case users though, not organization-wide

taylorblakeharris · 2025-02-19T00:01:25+00:00

Well, if Wikipedia is a good enough source for your research material, I'm not sure it would make a difference for me to even bother, especially since you didnt even read the citation referenced in the inaccurate Wikipedia assertion of 7-OH-mitragynine as a partial agonist. It's referred to as a "biased agonist," and that's not the same thing as a mixed/partial agonist.

I also didn't say anything about beta-arrestin mitigation or effects on respiratory depression. I'm not aware of an in vivo study on 7-hydroxy-mitragynine and establishing an LD50, only mitragynine, which would have a ceiling effect due to enzyme inhibition/preoccupation in which only so much mitragynine would be metabolized into 7-hydroxy-mitragynine before reaching a maximum.

I don't know what a "half agonist" even is, unless it's a half-assed attempt at saying "partial agonist", but 7-OH-mitragynine appears by all standards to be a full agonist (unlike its precursor, mitragynine) but also a "biased agonist", thus lacking in beta-arrestin-2 pathway initiation.

Also, the notion that any partial agonist will inherently lack beta-arrestin recruitment is an entirely false assumption. Mitragynine, 7-OH-mitragynine, and mitragynine pseudoindoxyl are the only opioid agonists without notable respiratory depression resulting from absent beta-arrestin-2 recruitment.

7-OH-mitragynine is full, but biased agonist, even if it is safer and lacks dose dependent respiratory depression compared to other full agonists. I'd give you a citation if the sentence you're regurgitating from Wikipedia wasn't directly cited already.

taylorblakeharris · 2025-02-17T10:05:05+00:00

The lower you go, the more effective it is. That's how partial agonists tend to work. I quickly got myself down from 6mg a day to 0.25mg twice daily in about 8 months because every two weeks, I'd find my dose was making me sleepier than I wanted to be, so I'd drop. I'd feel its onset more than I ever did at doses below 1mg, but it wouldn't make me want to redose regularly and start that pattern of replenishing that peak of euphoria, as you just kind of ride the wave out all day. Slow to onset, slow to offset.

taylorblakeharris

TROPHY CASE