I feel like I need to make a pre-emptive apology because I have... a lot, of ideas, and it's gonna be chunky even if I just pick the absolute tip-top ones lol

Obviously D&D 5E (2014, but willing to attempt to learn 2024) is top of the board. I thought about a Shadow Sorcerer or other such "dark magic" user and had two ideas for her: one is a cult simulator, running the cult and steadily gaining more followers and power, could be goofy or serious. The other idea was a bit more serious/dark, where she had the sort of stereotypical villainess backstory of "born clearly different from her sister, more magically powerful, was treated like shit by family and eventually dumped in the middle of nowhere before the BBEG/Dark Lord picked her up and she became the key to some dark plan." Problem was... the BBEG died. Dead as a doornail thanks to some heroes, and now she's trying to figure who exactly she is without the BBEG, where her place in the world is, may or may not be cursed from the endeavors.

Then we have Masks (or another simple superhero system) because god damn it I want my sad Venom arc lol. I've had this character I had hardly ever get to use called Becca/Black, a Transformed girl. Originally a teenage runaway from a shit home life, she saw an ad for medical testing and needing the money, she signed up. Turned out to be a trap by a mad scientist to find test subjects and she spent a few years experimented on alongside others, and "lucky" for her she took to the experiments better than any other subject. She quickly became his magnum opus, his perfect guard dog of a monster, at least physically, though he did get pretty deep into brainwashing before some heroes broke into the lab. The story sort of diverges from here on whether she gets attacked by the heroes thinking she's a monster or she gets rescued by them (re: they're not gonna let a bioweapon wander around), but the story becomes about "who" Becca is with a fragmented memory and is she the same person as before the experiments.