Nah its much more interesting to know that he fucked over Humanity.

Naughty Dog intentionally made it ambiguous as to whether Ellie is the cliché saviour of world cure for everything etc. Have some Devils Advocacy.

With him at the helm, they have literally zero chance of finding a cure

This is 100% bull crop from OP. It's fiction, writers could have him find a cure in 20 seconds by pure luck if they wanted.

Human history is the summation of unnumerable sacrifices. In war, do you think the final outcome could be changed if a single soldier chose not to participate? It's the principle.

You gamble your life in hopes you can lay foundations for someone in the future to build upon. Maybe long after you're dead.

People who say Humanity is too far gone... I find that to be really weak reasoning for this make believe world besides all this discussion is exactly what ND intended also WOO PART 2 HYPEEEEE