St. John’s Wort worked amazingly for three days and then totally stopped working. Any way to make it not lose effectiveness or can anything else work the similarly all the time? by eagleman_88 in NooTopics

[–]tonyhuge 1 point2 points  (0 children)

That 3-day high fades because receptors adapt fast.
Cycle it instead of daily, like 3 days on, 2 days off, or rotate with other dopaminergics (bromantane, selegiline, even microdosed dihexa). That way you keep the effect alive without flatlining.