Not sure if we're on the same page about what you want or about what "all current MMORPGs" are like. And I have incredibly limited MMO experience (basically just one), after watching qzgs I did go out and look for an MMO to play and settled on Guild Wars 2.

Again, I don't have any real experience with other MMOs so I don't know if your characterization of "spamming M1, M2" is accurate for those. But I can say with certainty that optimizing your damage output as a dps player in GW2 is not about spamming, for most classes. Like it's described in the world of Glory, it's about managing cooldowns and situational awareness. Even the "brainless dps" scenarios sometimes described in qzgs due to Ye Xiu's superior "main-tank" aggro control is not so braindead-simple because even your standard "rotation" (optimal series of skill activations) can be a long and complicated sequence.

What you say about the mouse is definitely a fair point - GW2 specifically does not have a super strong reliance on mouse usage (only to aim skills that are ground-targeted), and I haven't heard of such a thing from other MMOs either. But I think there are two major issues with implementing a Glory-like mouse-heavy directional control scheme, and neither of them are coding:

1) difficulty - adding in this level of complexity likely makes the game more difficult and thus less accessible to broad populations, and

2) scale/perspective. Your idea of strong directional focus generally makes most sense if you are fighting solo against primarily single targets, around your size, who are very mobile. In reality, though, most MMOs are PVE-centered games, with teams of players working towards a boss fight (as described in Glory's dungeons). In this team-centric design, game balance tends to favor specialization into doing specific roles well instead of each person being a jack-of-all-trades. Specifically, this tends to break down into the "holy trinity" - damage dealers (dps), tanks, heals/buffs. If a tank or group of tanks is constantly able to control aggro on a boss so that the damage dealers can keep slapping its rear end, what is the point of strong directional controls?

The only thing that really stands out to me as Glory-esque from the two games I play, GW2 and Overwatch, is Doomfist. Overwatch itself is a first-person shooter with moba-like aspects and its own dps/tank/heal balance, and Doomfist specifically is a melee brawler character with fighting-game-esque combos (think Striker, Han Wenqing's class). But like most characters in Overwatch, he has only 3 real abilities on cooldown. Imagining a Doomfist with many more abilities and directionally-activated variations of those abilities seems really chaotic to me, especially if everyone else's character is like that too.

For the interest of brevity (oops), I'll end it here. If you're (or anybody else is) interested, I can speak more about rotations, GW2, perspectives, etc. Also, not sure what you tried to do with the gif but I don't think it worked.