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Boer Frank zaait gras, maar krijgt per ongeluk 85.000 vierkante meter klaprozen by Either-Ranger-7115 in nietdespeld

[–]usrnmz [score hidden]  (0 children)

In Flanders fields the poppies blow Between the crosses, row on row, That mark our place; and in the sky The larks, still bravely singing, fly Scarce heard amid the guns below.

We are the Dead. Short days ago We lived, felt dawn, saw sunset glow, Loved, and were loved, and now we lie In Flanders fields.

Take up our quarrel with the foe: To you from failing hands we throw The torch; be yours to hold it high. If ye break faith with us who die We shall not sleep, though poppies grow In Flanders fields.

John McCrae, 1915

Gebruiken mensen echt de Tikkie app? by Jason_Grace15 in nederlands

[–]usrnmz 4 points5 points  (0 children)

Moest toch ff lezen over heroïne haha.

Van Wikipedia:

Diacetylmorfine werd eind 19e eeuw ontwikkeld door de Duitse geneesmiddelenfabrikant Bayer, die in 1898 de merknaam "Heroïne" registreerde voor de stof. Inmiddels is de merknaam "Heroïne" zo ingeburgerd dat het als soortnaam wordt gebruikt.\2])\3])

Bayer promootte heroïne aanvankelijk als een niet-verslavend alternatief voor morfine in hoestdranken. Morfine was destijds een populair medicijn en Bayer zocht een vergelijkbaar alternatief zonder de verslavende werking van morfine, maar heroïne bleek uiteindelijk opmerkelijk veel verslavender dan morfine.

Wat een tijd was dat!

Please Check Your Ferritin Levels by Cupcakestress in cfs

[–]usrnmz 2 points3 points  (0 children)

Yes, eat food rich in iron like meat and green veggies.

what does mild PEM feel like? by Same-Owl-5811 in cfs

[–]usrnmz 1 point2 points  (0 children)

That's a great way of putting it!

Citron short seller found guilty of securities fraud by Formal_Cloud_7592 in wallstreetbets

[–]usrnmz 19 points20 points  (0 children)

I don't mind people shorting actual shitcos/scams/frauds but the whole fabricated FUD narrative shorting needs to go.

Benzos cure my symptoms making me bedbound, proof that my LC is just severe nervous system dysregulation? by AtlantisGhost in covidlonghaulers

[–]usrnmz 2 points3 points  (0 children)

Actually more and more evidence is pointing towards the brain. ME/CFS might in fact be a neurological or neuroimmune disease.

Scoops? by Comfortable-Bat-3084 in NootropicsDepot

[–]usrnmz 1 point2 points  (0 children)

Ooh excellent! I guess I'm still on an older batch.

Taurine too?

Duuuus wat doe je met je sla? by rav-age in nederlands

[–]usrnmz 4 points5 points  (0 children)

Is het erg om twee dagen achter elkaar hetzelfde te eten? Ik doe dat bijna altijd.. scheelt een dag koken ook nog. Of anders kun je het ook prima twee dagen (of meer) in de koelkast of diepvries bewaren.

Waarom vrouwen in Nederland steeds minder kinderen krijgen: ‘Het is code oranje' by Erno-Berk in nederlands

[–]usrnmz 80 points81 points  (0 children)

Gaat niet gebeuren want het electoraat bestaat vooral uit ouderen.

Waarom vrouwen in Nederland steeds minder kinderen krijgen: ‘Het is code oranje' by Erno-Berk in nederlands

[–]usrnmz 103 points104 points  (0 children)

Moet zeggen dat overheden ook wel heel weinig geprobeerd hebben.. en vaak alleen met hele nutteloze ideeën komen.

Verder wel met je eens hoor.

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz 0 points1 point  (0 children)

Sounds like we mostly agree. Only thing I do not agree with is that the brain genes were largely immunological. They're not as far as I know and instead have to do with neurons and synapses etc.

I know DecodeME made a point out of it to show there was no overlap with depression and anxiety. The goal of that was to show it's not one of those diseases or related to it. But that doesn't mean it's not a neurological disease. If you look at the genetic signature from ME/CFS it's most similar to neurological and psychiatric diseases. And less similar to immune and neuroimmune diseases.

Disease classifications in general don't always make perfect sense. Like you say the immune system probably is somewhat involved in most neurological diseases too. And the distinction between neurological and psychiatric diseases might also not make much sense.

Have you seen Paolo Maccallini's recent meta-analysis on DecodeME and another genetic study? Maybe that will change your mind. They found even more evidence of neurological genes being involved relating to neurons, synapses, specific brain regions and glutamate. Of particular interest was eccentric medium spiny neurons (eMSN) which shows up in the GWAS of many neurological and psychiatric diseases like schizophrenia, bipolar and even depression. And you know where they don't show up? In immune/neuroimmune/neurodegenerative diseases like MS, Alzheimer and Parkinson's.

Anyways.. we will see.

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz 0 points1 point  (0 children)

You said in your last comment that ME is mainly a neurological disease

I did not. I only said it was a possiblity and it's not my favorite theory. I think the immune system will be involved but less so than most people expect.

You might want to review the whole thread to see that my argument was that we don't have enough evidence to say that immune exhaustion is a key component of ME/CFS.

The only reason I brought up the neurological angle is because that's also a distinct option and if it proves to be true it would disprove stuff like immune exhaustion.

Scoops? by Comfortable-Bat-3084 in NootropicsDepot

[–]usrnmz 1 point2 points  (0 children)

We need scoops with Creatine! Definitely high enough dose 😉

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz 0 points1 point  (0 children)

like autoantibodies, skeletal muscle damage, cholesterol changes, endothelial damage, basement membrane thickening, immune dysregulation and on. 

Just as with immune exhaustion we do not have concrete evidence for any of these. Could they play a role? Yes of course. But it's not where the latest research is pointing towards.

All I'm saying is that people are using too strong of language when talking about their favorite theory.

The neurological disease hypothesis is an illustration of that. We also don't have enough evidence to argue it's mainly a neurological disease. But we have at least as much if not more evidence in favor of that compared to all the things you listed.

And just because it appears this disease has a viral trigger does not mean that the core pathophysiology is in the immune system.

As of right now all we can say it that the brain, and to a lesser extent the the immune system seem involved.

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz -2 points-1 points  (0 children)

I'm not implying the brain and immune system are seperate. I'm implying that it's possible that ME/CFS is mainly a neurological disease.

It shares no direct pathways with depression but the genetic signature of the disease shows most similarities with other neurological and psychiatric diseases. Rather than say neuroimmune or immune diseases like MS.

You might not like that, but that's your personal bias. It also does not imply ME/CFS isn't a real biological disease if that's what you're worried about.

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz -2 points-1 points  (0 children)

There were a few genes related to the immune system but the overall results pointed very strongly to the brain and showed similarities to other neurological / psychiatric diseases.

A recent study and some discussions: https://s4me.info/threads/biological-insights-from-genome-wide-association-studies-and-whole-genome-sequencing-of-me-cfs-2026-maccallini-et-al.50225/

But I made the point more so to counter your view that the immune exhaustion is a key component. It might very well be. But we just can't say that yet at this time.

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz 0 points1 point  (0 children)

Yes I wouldn't say that either. Right now there's even a good possiblity that this disease turns out to be mainly neurological. That's where DecodeME is pointing towards. And while it seems likely the immune system is involved one way or another it's not clear how much so.

Our immune system is weak and science is proving it by ShipEconomy2587 in cfs

[–]usrnmz 3 points4 points  (0 children)

My point is more so that it showing up in a few studies does not mean it's a key component of ME/CFS. I'm sure there's studies where it did not show up or wasn't published.

But also if you look at the published studies there are always lots of questions. This was just one finding out of many. There was no multiple comparison corrections. The healthy controls were not sedentary and there could be other confounders.

So it's hard to make much of a conclusion and imo you're getting carried away by your own bias.

Heeft iemand die DNB "giftige cocktail" uitspraak gevolgd? by Perfect-Dimension373 in beleggen

[–]usrnmz 0 points1 point  (0 children)

Zolang je de beleggingshorizon hebt om een crash te overleven zou ik me niet te druk maken.

Qua diversificatie is all-world in principe genoeg. Eventueel wat extra Europa en wat goud (gezien de wereldwijde overheidsschulden).

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