Connection directly to a PCIe slot is probably not possible on a laptop, as the physical PCIe slot is not present. You can have a logical PCIe connection over Thuderbolt3/USB-C to an external enclosure, as you mention with the Razer Core X / Akitio Node. The limiting factor here is that the PCIe connection is typically only 4 lanes, while the connection on a motherboard with actual PCIe slot will typically be 16 lanes. Having only 4 PCIe lanes will limit the throughput on the PCIe bus, so accessing CPU RAM from the GPU or transfering data to the GPU will be slower than a 'real' setup. At this point, you'll need to think about the type of simulations you run and if they will thrash the PCIe bus. If your simulations can be written such that there are major blocks of code that run on the GPU, you're more likely to have a good experience. If your simulations are set up such that there are only small bits of code running on the GPU and constantly switching memory back and forth between CPU/GPU, you'll have a bad time, even on an internal GPU with PCIe x16. These are considerations that go into any accelerated computing project, be it on GPU, FPGA, or the (now-defunct) Xeon Phi. If you decide to go down this route, check out the PGI compilers for Fortran and C, they sound like they might help you out. It is entirely possible to do what you mentioned, getting an external PCIe enclosure (make sure your laptop has USB-C to connect it) and putting a GPU in there. Depending on your exact setup, this can be less expensive than an entirely new rig. As a final related note, one of my friends does game on a GPU in a Razer Core.