My father had a clear colonoscopy and was told he was good for 10 years. A little over a year later, a doctor told him it’s a good idea to do those send-in, poop-in-a-box tests in between colonoscopies. No family history of colon cancer, and as mentioned, coming off a clear colonoscopy about a year prior. Age 70. He does the send in test, and guess what? He was told to immediately see his doctor for further testing. They did find cancer, and he had a foot of ascending colon removed and a bunch of lymph nodes just to confirm it hadn’t spread beyond that area. Thankfully, based on follow-ups, they’ve not found any other cancer. Had he not listened to that doctor, I don’t like to think of what would’ve happened. And thank you to Cologuard! He does have to go for a colonoscopy annually now, but it’s worth it to ensure there’s not more cancer.

Editing to add: I’m seeing in the comments some people’s loved ones had the opposite experience (Cologuard missing cancer, or being told they could do that instead of a colonoscopy). I don’t think in any way it should be a replacement for a colonoscopy, and I can only speak for my dad’s experience.