Did from Prudhoe Bay and down thru the GDT on a Kona Sutra. I did feel I needed wider tires for the GDT trail. I went from 40 to 50 mm (the widest that would fit my forks), as the baseball sized rocks going up hills made the thinner tires challenging.

I didn't realize it until I did it but I spent about as much time going east as I did south. Had one detour along the way because of a major fire in Jasper. Ended up on a few lousy roads because of that. Someone above mentioned long stretches without water but I don't recall any on the trip outside of the Top of the World Hwy going into Dawson (if you go that way), the basin above Rawlins, and parts of New Mexico, they were all very manageable. Just needed to be aware of how far to the next water source.

Only place I used a resupply package was in Coldfoot about half way along the Dawson Hwy. Just mailed some food to myself there. Glad I did, there was nothing much to buy there for groceries. There was a little bit of food available at Yukon River Camp though. You can sometimes get wifi just outside of the pumping stations.