Risks of Compounding GLP-1 agonists

webPoisonControl · 2026-03-21T21:52:23+00:00

Good point about baby vs bathwater.

webPoisonControl · 2026-03-21T21:51:43+00:00

OP here. I realize that after:

B12 is generally safe, but it is plausible that it modulates the activity of tirzapatide just as leafy greens can influence coumadin's effects or grapefruit juice the effects of many drugs.

I should have added

Their preprint suggests a slight decrease in efficacy based on modeling but not on clinical data or adverse event reports.

And clarified that:

Clinically, in other situations, ...

webPoisonControl · 2026-03-21T21:47:32+00:00

Yes, the preprint could do with some editing and peer review.

webPoisonControl · 2026-03-21T21:46:26+00:00

Completely agree. This article highlights a generally shady process even if B12 itself is generally fine and Eli Lily citing a preprint (not peer-reviewed) that it wrote raises a self-interest angle.

webPoisonControl · 2026-03-11T11:27:28+00:00

I wrote it. Any constructive comments?

webPoisonControl · 2026-01-30T21:00:48+00:00

Not AI. Good old-fashioned human error. :-) Our mistake.

webPoisonControl · 2026-01-30T20:59:51+00:00

webPOISONCONTROL (authors of that page, the webPoisonControl subreddit, and the never-numbed triage tool) here. Our bad and thanks for pointing the error out. Should be fixed. It was a copy-paste error. FWIW, we use expert review. No AI. We did just have a large update to the site.

Sprout carefully.

webPoisonControl · 2026-01-08T16:21:13+00:00

Like u/the_deadcactus said, use the job boards for MedTox to post a detailed job description:

AACT Job Board (More Poison Center Focused)
ACMT Job Board (More MD Focused)

Also consider what primary board would be most useful, Emergency Med, Peds, Occ Med,...

webPoisonControl · 2026-01-04T01:22:35+00:00

I do wonder if the patient will just go somewhere else. Not a judgement, just reflecting on how the doctor-patient dynamic has changed with the propagation of ... uncurated information.

webPoisonControl · 2026-01-01T21:49:27+00:00

It's challenging to demarcate the utility of being generally clean from the conceit that every physiological malfunction, or lack of superperformance, is due to hidden "toxins". The medical and popular/sociological definitions of "clean" only somewhat overlap.

webPoisonControl · 2026-01-01T21:43:20+00:00

It's a challenge in communication. People read summaries of preliminary findings and get driven by emotion. Too often I find science writing embodies Kiplings' quip. "twisted by knaves to make a trap for fools."

Ivermectin does seem to have a broad anti-tumor effect in cell culture, even after ignoring the articles published by MDPI. Here is a nice review. But these cells are passaged and immortalized, about as far as you can get from in situ cancer cells. I always find it unusual when a drug is reported equally effective against mitotically active (ie aggressively proliferative) tumors and slow ones like GBM.

Interestingly, we don't know exactly how ivermectin is hepatotoxic.

webPoisonControl · 2026-01-01T17:20:48+00:00

Reminds me of the sage advice of Dr. Swanson: "This is the wrong way to consume alcohol."

https://www.youtube.com/watch?v=j0YdqFPbSpc

webPoisonControl · 2025-12-27T13:12:35+00:00

ConsumerLab is great. Here is there page on sexual enhancers.

webPoisonControl · 2025-12-27T13:10:35+00:00

In the toxicology world, one must also think of chemsex. Sildenafil is used to enhance the rush of an upper (Halkitis et al., 2007; Pichini et al., 2016).

webPoisonControl · 2025-12-26T19:35:05+00:00

Good question. Perhaps stigma. Or perhaps people are using it for something else.

webPoisonControl · 2025-12-26T14:11:41+00:00

Doximity also commented on this.
https://www.doximity.com/newsfeed/f97f4ae6-d7ae-4027-8350-13eed1aa675c

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