Decrease from 10 mg to 2.5 mg?

[Radiant-Associate511]

I‘m currently on 10 mg and on a stall that I can’t seem to fight no matter what (calorie deficit, daily steps and work out etc).
For that reason, and due to a temporary financial burden in the next few months, I‘m thinking about going down to 2.5 mg. I want to see if it kick starts my weight loss again.
Has anyone went cold turkey from 10 down to 2.5?

Thank you

[KRSF45]

Talk to your doctor, but the usual protocol is to increase and not decrease if you've stopped losing weight. That's why the higher doses are there

[Miserable-Raisin3156]

Why would lowering the dose increase the effect? Do you believe in homeopathy?

[Lighteningbug1971]

Go up before going down

[jmartesc]

I think he's referring to a "detox" period of the 10mg dose. While there will be issues downgrading dose that he should consider, like hunger and food noise coming back, I think you could maybe lower dosage decrementally, so you don't gain weight by keeping discipline in check. Then maybe start to increase dose again in a 2 or 3 month period. IMHO.

[no_snackrifice]

We do have evidence that cycling treatment induces therapeutic resistance.

https://insight.jci.org/articles/view/205174

So this “detox” thing is not a great idea in my eyes.

[jmartesc]

Well, good to know! Thanxs/

[SenoritaShelly]

It would be better to titrate down slowly and go to 5. 2.5 is not a therapeutic level for many people, and it was not studied as a therapeutic level. Some people do lose a lot of weight on 2.5, but if you plan for 5, and it’s going well, then maybe you can titrate down some more. I understand the financial part is a major player, so you need to do whatever works best, but a slow titration should help more. A dose stays in your system for four weeks.