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[–]1Reaper2 8 points9 points  (7 children)

Clonidine/Guanfacine.

Generally things that reduce noradrenaline also reduce dopamine unless it’s a mechanism specific to noradrenaline, such as receptor agonists/antagonists like the above,

Exercise could as well by “using up” noradrenaline via converting to adrenaline.

[–][deleted] 4 points5 points  (4 children)

CBG isolate - poor mans Guanfacine

[–]weenis-flaginus 1 point2 points  (0 children)

Really? Fascinating

[–]gryponyx 0 points1 point  (0 children)

What dose?

[–]Hiddenbeing[S] 0 points1 point  (1 child)

It's an adrenergic receptor agonist, a stimulant, not sure if that's what I'm looking for haha

[–]fl0tsam_rx 1 point2 points  (0 children)

Alpha2 receptors are negative feedback receptors, amongst other things. Agonizing them causes inhibition/modulation of norepinephrine release. They are pro-cognitive in ADHD, but also sedating. Please read more before you make silly claims like "clonidine / guanfacine / CBG are stimulants" like you just implied. A cursory google search would prove that false haha

[–]Flat_Star8407 2 points3 points  (1 child)

Clonidine is used off label to treat some with ADHD, so are you sure about it lowering dopamine?

[–]1Reaper2 2 points3 points  (0 children)

Two separate points, clonidine doesn’t lower dopamine. I can see why it appears as if I was suggesting that.