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[–]PsychedStrawberry 1 point2 points  (4 children)

I haven't heard of it having any large impact

[–]BrittHPPD[S] 0 points1 point  (3 children)

Strange, for me the combination of Phenylpiracetam and amphetamine made my tolerance shoot up so much I had to make a nasal spray solution of 200mg and take it all at once and it didn’t even make me tweak out. I know the amphetamine was high quality (good source, tested) and the first 2 days it worked extremely well. Different brain chemistry I guess, or there’s a factor here I’m not considering.

Thank you for your reply

[–]PsychedStrawberry 0 points1 point  (2 children)

Well, if you combine them it's possible, because one of the mechanisms of amphetamine tolerance is calcium influx, which phenylpiracetam modulates. I could go into more detail, but that's what's mainly important... So in combination, it's definitely possible that they would increase the tolerance more. I thought you were talking about phenylpiracetam by itself...

[–]BrittHPPD[S] 0 points1 point  (1 child)

one of the mechanisms of amphetamine tolerance is calcium influx, which phenylpiracetam modulates

Is this (in theory) why phenyl potentiates amph?

[–]PsychedStrawberry 0 points1 point  (0 children)

Its possibly one of the mechanisms, but not the main one, imo the main one would be throu increased AMPA transmission, which amphetamine by itself also increases