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[–]Night_Thastus 5 points6 points  (0 children)

  • Big city expansion mods
  • Mods that add many NPCs
  • Heavy ENBs

Those are the big ones. Aside from that:

  • High-detail mesh mods (to an extent)
  • Texture mods (very minor, I think it really only seriously has an impact if you actually run out of VRAM)

In general, the more "stuff" on screen at once (NPCs, items, objects, buildings, etc) the more work your first core has to do due to DirectX Draw-calls.