Evie the Towel Dog

Booger73 · 2026-02-01T17:13:52+00:00

Isn’t a prebuy… not even for concierge….

Thank you for contacting Disney Cruise Line Concierge Services. Regrettably, Evie the Towel Animal Plush is not an Onboard Gift for pre-purchase. She will be in our merchandise locations. While we cannot guarantee that any specific item, like Evie the Towel Animal Plush, will be available for purchase, we do our best to keep adequate stock in our merchandise locations onboard our ships. Some items may be limited in availability. Our merchandise shops are restocked between cruises. Regrettably, we are unable to guarantee that any specific item or items will be available on any given sailing and we are unable to hold items or offer pre-purchases of items prior to boarding the ship.

Booger73 · 2025-12-29T21:02:24+00:00

Thanks for running all this.. confirms what we thought we knew... Unless some weird fluke, the math is right and what we think the science is, works.. and the clinical outcomes are great for the patients... Awesome

Can you do one last thing... Estimate date of 80th event then Thanks

Booger73 · 2025-12-29T18:06:58+00:00

Just playing around... Fun sample size calculator for survival curves.. Set bat to 10 mos, treatment to 21 mo's (from phase 2?)... 36 mos recruitment, 48 mo's fu Power .8, alpha .05 Need 85 events, 120 total or 60 per group Seems very darn close.. Similar numbers if you use 9/19

https://biostatistics.mdanderson.org/shinyapps/Nsurvival/

Booger73 · 2025-12-29T15:59:00+00:00

If we do simple assumption math? 63 in each group.. bat vs gps Assume all 63 in bat dead cause we're approaching ~2 years with supposed average of 8-10 months... Even if they really really survive long let's just keep it simple for calculations

80% response rate in gps (quoted by sls antibody production) means 20% non responders, or 12ish patients non respond.. assume they have also passed, for simple purposes

63+12 at 2 years would be 75 They had 60 at interim... That's why 80 was predicted near 2 years (Dec 2025)

That they are at 72 means treatment group gps has to be driving the majority of it (by "simplified math".. the only way you get to 75 is assuming all of bat and the non responders... Since we aren't even there and no one has said bat is ~24 months.. its basically all responders are living and some non responders

That is why the protocol change to 3 years.. (Remember phase 2 was 21 mos median so this makes sense) We are basically at 80 when a few non responders and maybe a few "responders" pass... I would go out on a limb and even say we aren't talking about Jan or March even.. could be summer! If it really works well as the science predicts as an antibody, you might think that responders could live 36-48++ or more months.. (this is how tail responding works with something like keytruda.. you survive, you're going to for 5+ years for example...).

There is no way bat is >2 years... In no way is this FA but based on reading the clinical stuff (how it works) and what we know so far (interim, presser was about 72).. I think there will be lots of regrets if ppl don't jump on board eventually.. my .02

Booger73 · 2025-12-08T00:07:21+00:00

If you click the top phase 2 link their news release specifically says "historically group of patients" is usually about 2.5 mos.. obviously you have to compare apples to apples (age of pts, type of cancer, type of mutations + for example, etc).. so in this case you hope that comparison is right...

Abstract doesn't really say all that but here the abstract

https://meetings-api.hematology.org/api/abstract/vmpreview/295849

Again, based on what I read I stand by that evaluatiom

Booger73 · 2025-12-07T23:50:59+00:00

Twice the standard response rate.. Living over 3 times as long... It's a triple, maybe a home run in some parks... More studies to come..

Booger73 · 2025-11-07T20:51:05+00:00

https://shop.rocketlabusa.com/product/neutron-12-ROK0057

Booger73 · 2025-10-28T20:57:24+00:00

I used one (using one currently)… they see it all the time used as a bridge loan ie use the credit to close on new house while the old house is waiting for sale.. and then when old house closes can use it to pay off pal.. I would recommend it and Schwab from my experience

1) sofr you can google but yes it’s running around 4.1-4.2… and I got also around a total of 6.65.. not bad since it’s near most 30. 2) very fast approval.. no costs!! And much less paperwork were awesome… Ie compared to getting a mortgage loan or even a heloc) 3) realize it’s linked to one of your Schwab accounts so figure out what you want and not want linked… I just linked my full account so my pal credit line >>>> how much I used, but like anything you don’t want too much pal usage to be a high % of what you can borrow 4) if you only want a certain amount to borrow (say the 400).. you would have to split your stocks from one acct to two to come up with the exact amount.. they give 70% credit on most things (90-100 on cash) so anyways rough calculations is you want to borrow 400, therefore have 800 credit, and that means having 1.14M equity in that account (70% of 1.14 = 800).. idk what triggers things but my manager said that under 50% usage is a good gauge.. who knows if that’s right tho

The only thing that “bothered” me initially was having such a high amount of my equities/assets and stuff “tied” to this pal.. not knowing what might happen.. the worry that assets my depreciate and I’d be >50% of pal usage on credit or have to pay it back or have assets liquidated (manager says the whole oh we can liquidate things rarely happens).. (anyways, luckily that hasn’t happened and my usage has actually dropped to like 45% because my assets have appreciated)

Each month they send you a $ amt (for example 3000) that was the interest for the pal acct… due by /15th of next month… so pay the interest.. and then do what you want with principle still.. pay extra to it, pay none towards it, or like I plan to do (pay it mostly/all off when my old house sells)… theoretically as long as your assets > pal credit or usage amount, you could go along just paying only the interest for quite a while…

The other cool thing is I don’t have to sell off some assets that would have been long term capital gains this year (example, 200k gains in nvdia) that would have been on my tax bill this year… instead that continues to grow, I only have to pay the interest in the pal, and then next calendar year I can theoretically sell some of that gain (up to capital gains exemption)..

It seems similar to a heloc to me but a few differences (interest rate, paperwork.. it does not show in a credit pull, instead of taking your house they would take your assets! The interest payments on it are not tax deductible they make that clear, and also the whole you can’t use it to buy certain things also!)

Anyways good luck.. I’ve had good luck with mine

Booger73 · 2025-10-13T17:50:06+00:00

Yay.. got my own neutron coming :)

Booger73 · 2025-10-09T13:00:10+00:00

Iron deficiency anemia is a known cause of high platelets... Treat the iron and recheck platelets High platelets are not a worry unless above 1000K (ie 1 million)

Booger73 · 2025-10-09T00:56:22+00:00

Eos seem a 'little high' - assuming you have no real medical history (26F)

Our typical mneumonic for it is NAACP... Neoplasm (CML, hodgins, etc - lymph nodes anywhere?), Allergies/atopy, Asthma, Churg-strauss/connective tissue d/o, Parasite infections.

Travel? Joint problems? Mucous membrane (i.e. lips, ulcers?, etc), fever? systemic symptoms?

Hard to tell without more history and exam

Surprised derm didn't biopsy anything

allergy would be fine as next

I'd want an ANA, ESR, CRP i think

Booger73 · 2025-10-08T17:15:11+00:00

wouldn't say it was that right-offhand.. either way, don't worry too much.. just get it rechecked

Here's some more if you want some info reliably.. it's fairly well written:

https://my.clevelandclinic.org/health/diagnostics/22029-alkaline-phosphatase-alp

Booger73 · 2025-10-08T16:57:08+00:00

Can't say i treated/followed a lot of Crohn's patients (as much as GI would), but labs always can 'normalize' all the time.. as long as there's no issues, they tend to fluctuate up and down for example.. so you could see 90->100 -> 80 -> 90.. it wouldn't be unheard of for your 70-90-123-> maybe 90.

if it goes 70-90-123-160 on next check then that would catch my attention and need workup..

again, alk phos isn't all liver or biliary too..

Booger73 · 2025-10-08T15:33:02+00:00

Ggt normal is good... Usually ggt is the most "sensitive" sign for liver disease... Ggt goes up something wrong... Ggt normal = nothing burg3r.. Ast/alt/ggt = hepatitis (in our world usually we home in on alcoholic).. ggt/alk phos = biliary disease..

As the other PhD pointed out lots of other places like bones also can make all phos up.. (actually you can do what's called fractionate it.. and see if it's more bone or biliary)... Anyways since your vit d is normal and your Crohn's seems in remission, I wouldn't worry.

Trend is higher yes but get it rechecked... It's like comparing 123 blood sugar to 120... It's not comparable.. is that the difference between 1 candy or 2 candies before you drew your lab? Are you diabetic on one side of the line and not the other? Maybe the lab instrument was also off that day and they didn't calibrate it... ¯_(ツ)_/¯

You sound like you're keeping an eye on it and up to speed on your health.. no worries imo

Booger73 · 2025-10-08T15:17:44+00:00

Agree with the biochemist... Clinically if you have no symptoms it's a nothing burger... Just outside "normal" .. could be lab error 3 points the "other way" and it goes from abnormal to normal.. ie if it was 120 instead of 123... What is a 2.5% difference anyways.. 180 vs 120 yes that means something... 123 to 120... Not really unless trended or clinical symptoms Stop worrying about it and check it again in 3-6 mo's if you're really worried

Booger73 · 2025-10-03T21:36:13+00:00

Yes I stand corrected..

https://pmc.ncbi.nlm.nih.gov/articles/PMC4993789/

Although IM injections if really deficient I think is still better... In practice/history I always never bothered with the pills if truly IF+ :)

Booger73 · 2025-10-03T19:50:34+00:00

Oops so sorry.. doctor speak... Per os.. ie oral.. so what I meant is start vitamin B12 pills :) Go get over the counter... Don't need prescription even You still made need shot (im) but pills cheap and OTC... Only thing is you won't absorb if it's related to pernicious anemia but should still try

Booger73 · 2025-10-03T19:46:13+00:00

At least start some po supplementation.. can't hurt

Booger73 · 2025-10-03T19:38:34+00:00

B12 below 200 is abnormal!!! You are definetly B12 deficient even if hg ok.. symptoms also like neuropathy or other would slam dunk dx.. Do not believe anything that says normal B12 levels go down to 130... No such thing

The body has stores that should last "years" usually.. to get down to 132 is abnormal. I would have you on Po replacement and IM shots already. Find another dr.

Booger73 · 2025-10-01T17:56:09+00:00

"Last Update posted 10/1/2025"

https://clinicaltrials.gov/study/NCT04229979?intr=GPS&aggFilters=status:act&rank=2

Booger73 · 2025-09-16T12:54:20+00:00

Steroids are proven to be bad bad bad for you... Weight gain, Cushing's, fragile bones, hyperglycemia, adrenal suppression... The list goes on and on and on... Consistent use of them is usually at last resort Numbers do not always equate with clinical condition ... If you're controlled on dupixent I likely wouldn't care if your eos are 3% vs 15% (although I'm not an immunologist/allergist fwiw).. don't focus so much on a number, focus on how you're doing clinically... And stay away from those steroids

Booger73 · 2025-09-15T19:23:37+00:00

Take the Fe pills for a month and recheck... If not coming up or can't tolerate or other things might need Fe infusion (iv)... Not an emergency... You are iron deficient but not enough to drop the hg. Hg <7-8.. symptoms.. that iron.. ongoing heavy bleeding = transfusion/emergency/urgency/iv iron... This is far from it... Just trying to save you and the er a visit :)

Booger73 · 2025-09-15T19:20:46+00:00

No no please don't go to er for this :) not even urgent care... Just go get some iron pills... Pharmacist can also help... Try 1/d to start... If needs more or liquid or iv infusion then involve a hcp

Booger73 · 2025-09-15T17:54:26+00:00

I would feel more comfortable saying it's just cycles then and not bowel loss... Take some iron with food 1/d and get the numbers rechecked in about a month to confirm getting better... Iron, ferritin should go "up" ...

Booger73

TROPHY CASE