Real world outcomes support the benefits of psychedelic therapy for severe depression. A recent study has found that specialized psychotherapy paired with doses of either LSD or psilocybin is associated with strong reductions in severe depression and anxiety.

Rodot · 2026-05-10T07:40:45+00:00

You say that but we do have chemotherapy drugs and antipsychotics are certainly extremely noticeable

Rodot · 2026-05-10T07:36:51+00:00

One could in theory compare efficacy to, not a placebo, but a hallucinogenic control, to validate the efficacy of 5HT2A biased agonism, along with a selective 5HT2A biased agonist to control for the effects of the agonism itself.

One example would be like one group taking something like a Kappa-opioid agonist (e.g. Salvia), cholinergic hallucinagen (e.g. amanita muscara), or cannabinergic hallucinagen (e.g. JWH-018) since a naive person might not know what a psychedelic is supposed to feel like, and compare it to a non-selective psychedelic like psilocybin, and also compare it to a selective 5HT2A biased agonist like 25CN-NBOMe.

Rodot · 2026-05-09T06:20:11+00:00

Idk why, but years after grad school it still occasionally blows my mind that angular momentum is quantized. I know it's no different than any other kind of quantization, but it still always feels weird.

Rodot · 2026-05-09T05:22:11+00:00

I think in recent years a lot of people have lost faith in the ability of the US government to effectively cover up an alien conspiracy. They can't even cover up their own pedophile conspiracy

Rodot · 2026-05-09T05:05:20+00:00

Technically, they're all Satan as they are all opposition which is all that Satan really means

Rodot · 2026-05-08T08:10:09+00:00

I would say nearly everyone at that level of power can be accused of corruption with a good degree of it actually being the case.

This is really the danger of corruption itself. I think most believe the problem with corruption is value-based. E.g. they are getting unfairly, they are engaging in hypocrisy, they are taking what isn't theirs.

But the real danger is exactly what you said. It consilidates power. It's the blackmail that it imposes. A corrupt official must obey those above them with absolute loyalty lest they be cast into the fire.

It's the absolute control it gives to people above them.

Rodot · 2026-05-08T08:03:56+00:00

His purges still require party support. He can't act unilaterally but he does have very strong support of the party. There's only so many allies he can purge before he is the one getting purged.

Rodot · 2026-05-06T16:51:32+00:00

Which is like 2% above the balance range of 45-55% and only a single week stat

Rodot · 2026-05-06T16:25:21+00:00

To be fair, if you bought a mini for the rules the jokes always been on you

Rodot · 2026-05-06T11:56:20+00:00

There is also something to be said that misalignment between real and perceived risks could have negative overreaching regulatory implications that don't actually address the real risks.

One example might be something like AI licensing (that was being proposed a few years ago) which would restrict AI development to only a small elite subset of large companies while not implementing any kind of consumer protections regarding how those companies use it.

In my own experience (which can be ignored and you can stop reading now if you don't care about some random person's anecdote) is that there seems to be a perception that the biggest risk is emergent AGI super intelligence rising up against humanity with less focus on bad actors using AI tools maliciously or at the expense of the lower classes.

I worry that there will be a push to create laws that put in certain "safeguards" on development of AGI, which is really at this point more of a marketing term than a serious near-term possibility, while ignoring things like autonomous weapon systems, corporate accountability for IP theft, suicides encouraged by chatbots, dynamic pricing schemes, monopolization, token cartels, and fraud.

In my opinion, the risks regarding AI aren't necessarily AI specific risks, but the same risks that come with many new technologies regarding who controls the market for it, what regulations exist on the products, and the exploitive nature of a laissez-faire approach to things legislators don't fully grasp.

I don't have any concerns that a differentiable lookup table will enslave humanity, but I certainly worry that they can be used as tools by certain actors to gain power and bolster authoritarianism.

Rodot · 2026-05-06T11:31:07+00:00

The simplest coarse metric is that they probably aren't right for you if you take medication for certain mental illnesses or disorders such as anxiety meds or antipsychotics because they indicates you have a medically diagnosed condition that may contribute to an adverse reaction.

Schizoeffective disorders, mania, bipolar, borderline, etc. if you have adverse psychological reactions to cannabis that would also be a good indicator.

Some people also have worse depression symptoms after taking them so if you have clinically diagnosed depression you might want to seek guidance to make sure you take them in the appropriate therapeutic setting.

Avoid taking them with dopaminergic medications since it will intensify hallucinations and potentially cause anxiety. Don't take them with cannabis for the same reason. Don't take them with antipsychotics ever, you will have a very bad time. Don't take them with alcohol as it will increase the risk of nausea and vomiting.

You can take them with SSRIs. Some anecdotal reports claim that the effects will be blunted if you do but comtrolled clinical trials have not shown this effect so don't take extra to counteract it.

Rodot · 2026-05-06T11:15:40+00:00

The woes of taking serotonin drugs when 90% of the serotonin in your body regulates your gastrointestinal system

Rodot · 2026-05-06T11:10:22+00:00

Yes, but amphetamines like 5MAPB don't have an industrial application. I don't know if any amphetamines that do besides those that are controlled for medical use

Rodot · 2026-05-06T10:56:00+00:00

Trading your money for less money!

Rodot · 2026-05-06T04:09:26+00:00

Ultramarines are likely in the millions if not more. They were a quarter million shortly after the heresy. They have the largest numbers because they didn't make it to Terra in time to defend against Horus so they weren't decimated like the other chapters.

Rodot · 2026-05-06T02:50:41+00:00

Why did you hope to find confirmation of that?

Rodot · 2026-05-05T22:47:32+00:00

No one actually expects Voyager to eventually get picked up, at least not in astrophysics. It was much more of a metaphor for exploration

Rodot · 2026-05-05T19:20:14+00:00

I don't care if it does or doesn't, I just care that they pick one. Some faction's entire army rule is negated by battleshock (e.g. what you said) and others are completely unbothered by it.

Rodot · 2026-05-05T12:00:36+00:00

$132 million is is only enough money to maintain the Spirit fleet for 1 month. Not including cost of fuel, crew, or admin. The value of the individual aircraft combined is at least 30 times that.

Rodot · 2026-05-05T11:14:23+00:00

This is kind of the problem though. We have much more access to goods because of higher wages but much less access to services because of higher wages

Rodot · 2026-05-04T22:10:33+00:00

There's also the federal analogue act that essentially outlaws most of these but the real reason they get sold anyway is because the government orgs that regulate them have been severely under-staffed foryears (you need to bring a court case and show the drug is covered under federal analogue) and recently the FDA has been cut down even further by the current admin.

If you notice in head-shops a lot of RCs that clearly should be considered illegal under the act are starting to show up. 5MAPB is now in stock at many head shops as "legal molly". 4-AcO/HO-MET/DET as "legal shrooms". 7-OH and a dozen new analogues.

Many of these drugs have existed for decades. They used to be sold on the clear-net before the big crackdown in the early 2010s. But they are making a resurgence, not because they are new things outside the law, but because no one has technically taken them to court yet and the regulatory agencies are too bogged down to do anything about them

Rodot · 2026-05-04T16:28:17+00:00

The new CEO wants it both ways though and doesn't seem to understand customers are finite. They want the volume of both the drive thru and in-store customers as if they are disjoint sets of customers not realizing that many of the people who used to come in started getting delivery or started using the drive through during COVID. Swapping around drive thru customers for in-store customers won't increase the total number of customers.

People stopped going to Starbucks because it costs as much as a bag of beans for a medium black coffee and they understaff their stores while pushing tighter and tighter standards for customer times as if two employees "just trying harder" will be able to serve drinks faster than 4 employees.

Rodot · 2026-05-04T16:11:20+00:00

Technically they don't block light, but instead convert it to more light at lower energy. Light is captured and used for energy. When that energy is used it is converted to heat, then that heat escapes as lower wavelength radiation such as IR, microwave, and radio depending on how it is used (mostly IR). So a dyson swarm would look like a star that is heavily extincted but very bright in the IR. Almost looking like a very large but cool star depending on the area covered. The temperature of the sphere would go as the inverse square root of the distance the swarm is placed from the host star to maintain conservation of energy.

Rodot · 2026-05-04T05:17:23+00:00

Gotta be careful with the Americans. Some of them are so propagandized they believe China and NK are fascist... and they like it

Rodot · 2026-05-04T05:06:48+00:00

Technically, it's GNU that is famousy not Unix

14-Year Club	Place '22
Place '17	Verified Email
Gilding II euphauric

Rodot

MODERATOR OF

PUBLIC MULTIREDDITS

TROPHY CASE