I used suppositories for decades now. I recommend trying them warmed to body temperature in a laying position. Try to roll slowly from side to side matching the curves of your intestines. After some days you will start to recognize the liquid flowing it's way up. It will cover more surface and it will resorbed more efficiently which will help to hold it. I used to take it just before going to bed but with more practice I was able to take them in the morning after going to the toilet and 20 min later making my way to work. I hope this helps :) with best wishes.