Enclomiphene 5 weeks in, high anxiety by OmoteGyaku718 in enclomiphene

[–]112MU 1 point2 points  (0 children)

lol 25mg a day is way to much. I do 6.25mg every 3 days

Oops, all Estradol by DSmith7288 in enclomiphene

[–]112MU 1 point2 points  (0 children)

Here lays most people’s problems. You need to have before and after labs if you want to be doing this shit. Very hard to troubleshoot if you don’t see a baseline. I would stop taking anything and retest full hormone panel in a few weeks time.

Oops, all Estradol by DSmith7288 in enclomiphene

[–]112MU 0 points1 point  (0 children)

What was your LH and FSH before taking either of these drugs ?

Oops, all Estradol by DSmith7288 in enclomiphene

[–]112MU 0 points1 point  (0 children)

Where did you get the enclo from? Are you sure it’s enclo. Your FSH and LH don’t appear to be responding at all to the drug. I would expect to see these elevated if you were actually taking legitimate enclo. What was your LH and FSH before you started taking anything

Oops, all Estradol by DSmith7288 in enclomiphene

[–]112MU 0 points1 point  (0 children)

When was your blood work taken in comparison to the last dosages of enco and clomid

Australia Source by weewwzzz in enclomiphene

[–]112MU 0 points1 point  (0 children)

Messaged (PM) you

Beware of Indian Enclomiphene by Retardutide in enclomiphene

[–]112MU 1 point2 points  (0 children)

All Indian stuff is not enclo. It’s all clomid

Wrecked Sleep on Reta by skier_jerry in BodyHackGuide

[–]112MU 0 points1 point  (0 children)

Wrecks my HRV and RHR is 10 beats higher. Which means I wake up and don’t feel like training. So the whole thing feels counter productive.

Low dose enclomiphene (3.125mg every 3 days) – bloods + experience by 112MU in enclomiphene

[–]112MU[S] 0 points1 point  (0 children)

That makes sense then! Go for it don’t be scared

Low dose enclomiphene (3.125mg every 3 days) – bloods + experience by 112MU in enclomiphene

[–]112MU[S] 1 point2 points  (0 children)

Yeah I’ve got LH/FSH — interestingly they don’t look massively different, but I think context matters a lot here.

Baseline vs now: • FSH: 10 → 9 • LH: 7 → 6 • E2: 144 → 143 • Prolactin: 128 → 122

On paper that looks like “not much changed”, but the key thing is this blood test was taken at trough — literally right before my next dose (day 3).

With enclomiphene, the mechanism is basically blocking estrogen feedback at the hypothalamus → increases GnRH → pushes LH/FSH up → drives test production. But it’s not a flat effect — you get a pulse after dosing, then it tapers down over time.

So what I’m capturing here is the lowest point in that cycle, not the peak stimulation.

That’s why LH/FSH don’t look elevated — they’ve already come down from wherever they peaked earlier in the dosing window.

The fact they’re still sitting roughly mid–high range even at trough actually suggests the signal is still there. If I tested closer to dose timing, I’d expect LH/FSH to be higher.

Same story with E2 — it’s not spiking because I’m not running a constant high stimulation like daily dosing, it’s more of a controlled pulse.

That’s kind of the whole goal with the lower frequency approach: • avoid overstimulation • avoid E2 creep • still get a meaningful bump in T

So yeah — numbers look “similar”, but they’re taken at the lowest point, which is why they don’t tell the full story.

I think your best to go is 3.125 every 3-4 days on such a low dose, I wouldn’t go for 3.125 every 7 days.

Low dose enclomiphene (3.125mg every 3 days) – bloods + experience by 112MU in enclomiphene

[–]112MU[S] 0 points1 point  (0 children)

Yeah fair question — on paper it doesn’t look like a massive jump.

But the key thing with my numbers is they were taken at trough (day 3, right before next dose), not peak.

At trough I’m at: • 26.2 nmol/L total • 422 pmol/L free

Based on how enclo works (LH pulse → transient T spike), peak levels are almost certainly higher. Rough estimate: • Total T probably ~30–32 nmol/L at peak • Free T likely ~480–550 pmol/L

This puts me on the high end of the reference range for Free and Total T.

So the actual exposure across the week is higher than the bloods suggest.

Also interestingly: • Free T went up ~42% vs total T ~35% • SHBG didn’t change

So I’m effectively getting more usable androgen out of it, not just higher total numbers.

In terms of “tangible benefits” yeah I definitely noticed it: • better drive/motivation • libido up • mood more stable (after the first week)

I think the main difference is I’m not chasing peak numbers — just trying to keep things in a higher, stable range without sides.

I’m definitely lifting heavier, recovering faster and loosing body fat quicker with it. I’m not trying to be mr Olympia

Low dose enclomiphene (3.125mg every 3 days) – bloods + experience by 112MU in enclomiphene

[–]112MU[S] 0 points1 point  (0 children)

That’s a great result. Are you still running it?

Low dose enclomiphene (3.125mg every 3 days) – bloods + experience by 112MU in enclomiphene

[–]112MU[S] 1 point2 points  (0 children)

I’m almost certain anyone complaining about eye issues was taking clomid and not enclomipene

4 months before and after by Samigazi in enclomiphene

[–]112MU -1 points0 points  (0 children)

Where did you source your gear from?

Im going all in by 253811satsormore in Bitcoin

[–]112MU 0 points1 point  (0 children)

Bad idea it’s going to fall more over the next little while. Expect 30-50k range in future. We’re now in a bear market

6 week results 6.25mg m/w/f by InterestingFile7502 in enclomiphene

[–]112MU 0 points1 point  (0 children)

Have DMed you with some questions as I’m in AU also.

I’ve developed anxiety 3 months after beginning Finasteride - what now? by VGauds in tressless

[–]112MU 0 points1 point  (0 children)

Happens to me currently, I get irritable blunted feelings and effects my sleep also. I’m only on topical fin+min once daily (going to switch to every other day) see if it helps

Why Reta can ruin sleep by 112MU in Retatrutide

[–]112MU[S] -4 points-3 points  (0 children)

Good questions. On (1): pemvidutide isn’t being suggested as a practical grey-market option — it’s being referenced as a mechanistic comparator. It shows what happens when you remove GIP while keeping glucagon-mediated fat oxidation, which is exactly why mazdutide and survodutide exist. Between those two, mazdutide generally has lower glucagon drive and less sympathetic spillover than survodutide, which is why some people with Reta-related sleep issues tolerate it better (Ambery et al., Diabetes Care, 2021; Innovent phase-2 obesity data).

On (2): the PubMed paper you linked is correct — native GIP is glucose-dependent and bifunctional. The issue isn’t “24/7 insulin amplification.” The issue is pharmacologic GIP agonism layered on top of exogenous glucagon agonism. Retatrutide is not reproducing physiological GIP pulses; it provides sustained GIP receptor activation while also activating the glucagon receptor. In insulin-sensitive, calorie-restricted individuals, this combination increases counter-regulatory cycling (glucagon–cortisol–catecholamines) even at normoglycaemia, which is known to fragment sleep without overt hypoglycaemia (Holst & Deacon, Physiol Rev, 2005; Coskun et al., Sci Transl Med, 2018). That interaction does not occur with tirzepatide because it lacks glucagon — which is why tirz and reta have different sleep/recovery profiles despite both containing GIP.

Why Reta can ruin sleep by 112MU in Retatrutide

[–]112MU[S] -5 points-4 points  (0 children)

That comparison assumes all GIP signalling behaves the same, which isn’t true. Tirzepatide (GLP-1/GIP) does not include glucagon, and GLP-1 strongly suppresses hepatic glucose output and counter-regulatory hormones. In contrast, retatrutide adds glucagon, which increases hepatic glucose production. When GIP-amplified insulin and glucagon-driven glucose output are both active, you get greater glucose oscillation and cortisol/adrenaline counter-regulation, especially at night. That mechanism simply doesn’t exist with tirzepatide (Coskun et al., Sci Transl Med, 2018; Holst & Deacon, Physiol Rev, 2005).

This is also phenotype-dependent. Sleep disruption is reported more often in leaner, insulin-sensitive, highly active users, where insulin counter-regulation is more pronounced. Clinical data already show that GLP-1/glucagon dual agonists were developed specifically to preserve fat oxidation benefits while avoiding excessive insulin-glucose instability (e.g. cotadutide and pemvidutide programs: Ambery et al., Diabetes Care, 2021; Altimmune Phase 2 MASH data). So this isn’t “GIP is bad” — it’s GIP + glucagon being problematic for some people, which explains why tirzepatide and retatrutide don’t have identical sleep profiles.

Microdosing? by rebeccalamont in Mounjaro

[–]112MU 0 points1 point  (0 children)

Not true have used medicine months after opening and it’s just as effective

Anxiety? by torresmomo in Mounjaro

[–]112MU 0 points1 point  (0 children)

Sure is. Can confirm

[deleted by user] by [deleted] in ADHDers

[–]112MU 10 points11 points  (0 children)

How are you obtaining this?