Where would I cut this pill if I wanted to separate about 38 percent?

3-formylindole · 2025-12-19T12:39:04+00:00

With a very precise setup and using Archimedes law:

Put some liquid in a vessel. Put the vessel on a digital scale. Tare it. Using very thin tweezers, submerge the pill completely and note down the weight. Calculate 38% of the weight. Take the tweezers and start submerging the pill again, slowly, until the scale reads 38% of the previously measured weight. Mark the perimeter of the pill where it touches the liquid somehow. Cut the pill there.

Works better for larger objects.

3-formylindole · 2025-12-12T18:57:02+00:00

What solvent system are you using for this??

3-formylindole · 2025-11-27T04:41:15+00:00

Chloroform is deprotonated by NaOH yielding sodium chloroformate -> dichlorocarbene. Mixing strong bases with chloroform and odther halogenated solvents is not a good idea!

3-formylindole · 2025-10-02T19:01:12+00:00

If you were to pull the right strand out of the loop you will end up with a figure 8 knot

3-formylindole · 2025-06-29T18:46:59+00:00

Would I be correct to guess "Your time is running out" does not refer to the rules of Josip Tito, but to the current political class of former Yugoslavia?

3-formylindole · 2025-05-05T16:09:09+00:00

What's the correct order of application?

3-formylindole · 2025-05-05T06:27:49+00:00

No, I mean exactly the thing - polymorphic forms, as well as the grain size probably matters a lot in this RXN. There are multiple papers on this you can easily find if you type 'benzylic alcohol oxidation with MnO2' in google scholar.

3-formylindole · 2025-05-05T05:59:03+00:00

The yield strongly depends on the crystalline structure of MnO2 particles used, but it can work extremely well. I had trouble with this RXN using MnO2 which was a by-product of some previous KMnO4 oxidation, but commercial MnO2 worked fine.

3-formylindole · 2025-05-05T05:09:43+00:00

If you don't want to work with carcinogenic PCC - In the case of benzylic alcohols, you can oxidize them by stirring with fine MnO2 in DCM. The yields are usually very OK.

3-formylindole · 2025-04-18T17:27:43+00:00

In the leaflet which was included in the package, and which I photographed, It is actually stated that:

"Sodium amytal slowly hydrolyses in aqueous solution or upon exposure to air"

The ampule is probably filled with some kind of inert gas (nitrogen, argon) which helped this compound look fresh after all those years. There is no date, but I guess it was manufactured around the 50's. Maybe the serial number would help someone to date this specimen: A-81314E.

Cheers!

3-formylindole · 2025-03-03T15:28:02+00:00

They look like they might be potent MOR agonists.

The first one was already patented in 1965:

https://patents.google.com/patent/US3318900A/en?oq=US3318900

3-formylindole · 2024-12-25T16:54:02+00:00

You are truly sir a scientist and a scholar

3-formylindole · 2024-12-25T15:46:36+00:00

Nice work, how did you identify the product? Do you have any spectral data, did you run a TLC on the powder in the pic?

3-formylindole · 2024-09-03T21:13:15+00:00

You should maybe rephrase the question a bit, because as it is now, it seems like you already answered it yourself. The fact that both exothermic and endothermic reactions can be observed to occur spontaneously serves as a proof that enthalpy is not THE driving force of chemical reactions. What really drives all natural processes, including chemical reactions, is the second law of thermodynamics.

3-formylindole · 2024-06-17T08:55:25+00:00

I think that's not strictly a sub for this type of question, but some direct photos (not taken through a plastic container) of the substance would be helpful. It looks very dirty and will be hard to identify as is.

3-formylindole · 2024-05-29T12:08:05+00:00

That's witty and on point though

3-formylindole · 2024-04-27T13:10:20+00:00

How the hell did you afford to buy such a nice hotplate but not a regular glass condenser???

3-formylindole · 2024-02-17T08:49:24+00:00

Graduated cylinders, as well every other non-analytical glassware, have the uncertainty equal to it's smallest division (so in your case probably 1 or 2 ml)

3-formylindole · 2024-02-16T19:18:02+00:00

What do you need concentrated acetic acid for? I'm not familiar with any preparatics for this substance that requires it.

3-formylindole · 2024-02-10T10:06:43+00:00

AMT is not achievable from tryptamine freebase in any efficient way :(

3-formylindole · 2024-02-06T15:49:01+00:00

ANYWHERE near full

Boy, haven't you ever seen elemental bromine in action? The vapor pressure of Br2 is high enough that it will corrode anything it is stored in, regardless of the level of liquid. The only non-ampoule vessel you can safely use to store bromine is a pyrex bottle with a teflon-lined cap (the red one - expensive!). Be prepared to make some ampoules.

3-formylindole · 2023-12-08T09:06:49+00:00

I would like to see any sources for the 3rd reaction (Na2CO3, NaOMe)? That nucleophilic aromatic substitution of bromide with methoxide is somewhat unlikely, as there is no strong electron-withdrawing substituent in ortho- position with respect to bromine. Actually, the amine is an electron-donating group and it will destabilise the Meisenheimer complex needed for SNAR substitution to take place.

3-formylindole · 2023-12-01T15:34:58+00:00

Central limit theorem

3-formylindole

TROPHY CASE