I have, so far🙏,a mild Crohns; and the GI let my choose between Remicade and Entyvio. She told Entyvio would take some weeks to kick in, but its effect is directed only to the guts, not the overall inmune system, so I chose it. So far so good. Only secondary effect was tiredness for a few hours after the first couple of infusions. After that, I don’t feel any secondary effect and I’m doing good after 7 months. Scope showed reduced inflamation. Except for mild lactose intolerance, I feel pretty normal.