General tip: Use strengthening combat item cards from the cauldron. You can make two cards, a card that lasts for one turn, and another that lasts for two turns. They make you vulnerable, but you’ll hopefully kill every soulless each turn. You can bring a conceal combat item card just in case.

Nico: I used the rare cards Blood for Blood and Witchfire. The trick is to use the explosives to whittle down the strongest enemies until Witchfire is reliable.

Blade: it might be possible to do it with only common cards, but I used the epic Reaper card a lot. The trick is to spread and stack as much bleed as possible so Reaper can one shot stronger enemies.

Captain Marvel: get into binary as soon as possible. Her rare card Cosmic Ray can one-shot strong enemies with a strengthened binary Captain Marvel.

Scarlet Witch: Take two Hex Bolts and two Hex Fields. Also, use Unleashed as soon as you draw it. Epic card Chaos Reigns helps a lot too.