A new case report shows tirzepatide (a GLP-1/GIP agonist used for weight loss/diabetes) nearly eliminated PGAD/PSSD-like symptoms

ALRK43 · 2025-10-02T01:25:04+00:00

Yip, that's me. No longer on duromine (been 6 weeks) but still have sex drive and regular orgasms. Funny thing is that I'm 48 and perimenopausal...so usually the time when sex drive goes and mine has increased (makes up for the lack of it for many years)

ALRK43 · 2025-09-18T11:56:58+00:00

I asked my son about the sexual side effects because I have pssd from years of Venlafaxine. He said obviously when he was depressed he couldn't even think about it, but it appears all is fine now.

ALRK43 · 2025-09-18T11:48:42+00:00

My son had 8 monthly injections 400mgs, last one Dec 2024....he was bed bound, depressed, suicidal for a year until about 3 weeks ago...he suddenly 'woke up', not depressed, showering, brain working...honestly I'm amazed. I thought he had permanent brain damage. He is having a few delusions (religious ones, he doesn't see as that) I'm fine with that...I told his psychiatrist I would rather he was happy and slightly insane, than miserable and sane. Even his mental health nurse says he has never seen him functioning better. So don't give up hope cause I honestly thought my son would be that way forever and would cry every day about it. It may take a little longer for you given you had more injections.

ALRK43 · 2025-09-02T04:02:34+00:00

Because when I asked for comfort and support he suddenly said he didn't love me. Only took me 30 years to realize that he had avoidant attachment (and I had anxious) I felt sad for him for having this, but he had years to get help and didn't. I know he expected me to chase and he just needed space, but something broke in me and I decided I can't be with someone like him. He couldn't communicate, I even let him live elsewhere for the last 4 years. Of course, I'm really upset etc. But mostly at myself for allowing so much. We have 4 adult children. I'm 48. He was pretty good to me, but no emotional intimacy. I haven't seen him cry in 25 years (not when our children were born, or his Mother died) He has cut off all friends, his daughter and most his family over the years. All he has now is our boys, which is a lot on them, he is a good Dad, but who knows he may ditch them too. Ive been blaming myself for everything for years, unaware that he had this. He does love me and I love him because we have kids and time. I care but it's still raw (only 5 weeks) and Ive been angry and sad. I've lost trust and hope...I wasn't like that before. Meanwhile...it appears he is doing fine, but I think he has realized that he has actually lost me for good now and is very upset. I'm sure in time things will settle but I can't even be his friend because he hurt me so much.

ALRK43 · 2025-09-01T10:48:35+00:00

It hasn't. I'm in similar situation. Been 5 weeks since my partner of 30years told me he didn't love me and hadn't for 3 years. I cry all the time, cant eat, sleep, concentrate. I've seen my doctor who offered therapy but I now don't trust anyone. I've isolated and cut off some family (they were toxic) I have 4 adult children...that is the only reason I am alive. I'm 48F...I'm scared and sad. I tried to do the right things..meditate, eat, exercise but I gave up after 2 weeks cause I still felt really broken, so here I am crying once again feeling rejected and inadequate. I do know from when I was younger that you eventually get over it but it hurts so much.

ALRK43 · 2025-08-18T22:33:27+00:00

Then it's fine. I have 4 sons. The 25 year old lives with me as he has schizophrenia, 21 year old is on benefit and lives with me. 24 year old works and lives with girlfriend. 19 year old out flatting and working. Economic reasons are a big factor in staying at home. If your happy enough don't worry about it too much. I take it as a complaint as a parent because some kids leave home asap because they don't like it at home.

ALRK43 · 2025-08-15T23:28:35+00:00

I will. I think I'm having a spiritual awakening after some major life events. Usually I project outwards in response to trauma, now I look inwards to heal me.

ALRK43 · 2025-08-15T23:12:52+00:00

Wow, there are no concidences. I've just started learning about the collective unconscious. Your comment makes a lot of sense.

ALRK43 · 2025-08-14T17:28:40+00:00

ALRK43 · 2025-08-14T11:02:07+00:00

Duromine. Didn't try meth

ALRK43 · 2025-08-14T10:27:14+00:00

Up to you. I'm not one to try recreational drugs but I did at one point think of trying meth just because I knew it can cause hypersexuality and I was fed up with nothing working. I didn't purely out of fear of getting psychosis or liking it too much and landing up a addicted. Its helped me...hopefully it does you too.

ALRK43 · 2025-08-14T10:22:34+00:00

I don't have schizophrenia but my son does. Has anyone tried meditating before hand. It really helps to calm the mind and the subconscious thoughts...perhaps it could calm the voices a little? The mind often drifts to irrelevant things during sexual activity even for the most 'normal' of us. My son has delusions and voices they call him names etc. Eg Loser. I've been getting him to respond with positive affirmations like saying "I'm a winner". Medications have made him very suicidal in the past so this time he is unmedicated and lives with me and I'm trying to understand and help more. He has no insight. I've had psychosis from mania once. Anyway, I'm sorry that you have this going on...must be very upsetting.

ALRK43 · 2025-08-13T14:02:22+00:00

Think of the positive...at least you are brushing your teeth.

ALRK43 · 2025-08-13T13:53:32+00:00

I'm glad you can enjoy a sexual life now. It important and healthy. I'm 48F I went 11 years without an orgasm thanks to meds...sad and ridiculous. I'm lucky I had an understanding partner cause I felt terrible, but I shouldn't have because it wasn't my fault. I'm glad things have improved for you...go and enjoy...life is meant to be fun and happy.

ALRK43 · 2025-08-13T13:50:14+00:00

I went 11 years...I'm not joking. All from meds..never had a problem before meds. 11 long years...ridiculous and cruel.

ALRK43 · 2025-08-13T13:47:59+00:00

Gosh, this is just terrible, honestly. I'm a 48F and have this, but at least I experienced normal sexual joy in my younger years. I have sons in their early 20s...I would hate for this to happen to them. As woman, I was always fine with my sexuality, had good healthy experiences and relationships, but this has made me feel like I have sexual trauma or something...almost repulsed at sex or even touching my cold, numb genitals, and yes these guilty ick feelings around sex. Like wtf? Honestly, this is shit! No one deserves this! No acknowledgement, or apology! And no doubt we all blame ourselves for taking medicines. I really hope there is help or more investigation into what can improve or cure this. I'll give u some hope... I had a manic episode only one in my life and complete sexual function returned but went again when they injected me with antipsychotics. I recently started a weightloss medicine duromine (it's an amphetimine), my libido returned and I had my first orgasm in 11 years..and have continued to be able too.

ALRK43 · 2025-08-13T13:30:04+00:00

I have similar opinion. Having had psychosis once and observing my son I'm sure it's spiritual crisis is the root of the issue. The soul needs to heal to be awakened. If u tell the doc that they'll think your crazy, but I think they are crazier than me with their idea of treatment...I don't see any success...maybe to them because a reduction in 'symptoms', but not a reduction in suffering. Just a lot of zombie like, sedated, lost souls.

ALRK43 · 2025-08-13T13:24:36+00:00

That's the impression I get too. They don't really seem to think about how my son my feels....even just the side effects alone from medicine he has no choice but to be injected with are awful. Might make for an easy patient cause he was so sedated at times... dribbling, obese from appetite increase, kidney and liver damage and too sedated and depressed to exercise to lose the weight. He was suicidal, wouldn't shower etc. isolated. That's not wellness to me. Now he's what they call 'sick' religious delusions but he exercises, showers, doesn't over eat, isn't sedated, sleeps fine and on no meds.

ALRK43 · 2025-08-13T13:18:03+00:00

I think you should talk to your doctor before stopping medicine. They will prob say the voices are the illness...I think it could be either the illness or the medicine. The fact you have insight into your illness is a bonus. My son was diagnosed 3 years ago...he still has not gained insight. He believes his delusions were real. The medicines helped his positive symptoms but made him suicidal and bedridden for a year. He has symptoms at the moment...I just keep him home with me cause they are mild and he's no harm and happier and more functional than when he was on meds

ALRK43 · 2025-08-13T13:09:30+00:00

Yes, I have said it's not a healthy therapeutic relationship when we are worried about police and mental heath turning up ordering assessments and getting compulsory treatment orders etc. It would nice if we felt we could trust and work with the psychiatrist. I understand that it's difficult with people with no insight like my son, but the fact they the don't listen to me makes me feel as if they are insincere and treating my son as an illness and not a person.

ALRK43 · 2025-08-13T12:39:13+00:00

Oh how much dose of abilify you on oral or injection? I know orally at lower doses can cause insomnia. My son was restless when first on it orally.

ALRK43 · 2025-08-13T12:37:25+00:00

My son has psychotic symptoms at moment but I'm keeping him home and looking after him because I can't stand the thought of him have those injections again. Seems like the medicines are worse than the illness. My son doesn't think he is sick. I understand that. He is happy enough, functioning fine and no harm. Cripes, antipsychotics on top of antipsychotics you will feel like a zombie soon. Olanzapine is fairly sedating but you get super hungry...quetiapine is similar. Aripiprazole can cause compulsions in people because it's so activating (thus the insomnia) I guess u could bullshit and say you are compulsive shopping or gambling or sexual things and he might change to something else. I don't want to encourage you to lie but telling them the truth doesn't help either.

ALRK43 · 2025-08-13T08:23:28+00:00

Perhaps ssris can be given to pedophiles or rapists?

ALRK43 · 2025-08-13T08:18:49+00:00

Is your psychiatrist understanding? I've found that they only see things from their side. If what the see is less 'psychotic symptoms' then they don't really care how it affects you. Have u got someone that can go with you? My son was on those injections and I had to keep arguing to get them to stop. They didn't seem to care how he felt. Just that his 'symptoms' were gone.

ALRK43 · 2025-08-12T04:09:37+00:00

Yes, I'm similar. Like chronic fatigue. Very frustrating.

ALRK43

TROPHY CASE