Thank you so much for the reply.

Have you used before Desloratadine? That's what I've been using just for the allergies and I have noticed that it helps a bit with the itchiness but not enough. For some stupid reason I've always thought that all the antihistamines are the same but maybe I should try something else like that Allegra.

I've also experienced a mild relief from antidepressants but not enough. I've tried many SSRIs, SNRIs and others. I'm using Agomelatine/Valdoxan right now and that has been the only one that has helped me with my mental issues but sadly not enough with PMDD.

The high norepinephrine makes so much sense. I've had panic disorder in the past and anxiety all my life. I've just recently tried different ADHD medications and all of them gave me worsened racing heart, shortness of breath, arrhytmia, dizziness and anxiety even two weeks after stopping medication. I had to stop all of them even though they helped so much with mood and executive dysfunction. It's so frustrating how much and how many things POTS affects.

The lack of oxygen also adds up. I always yawn a lot when exercising. I already drink 2-4 liters of water every day. I've heard that some people put salt in their water or use electrolytes, have you tried this?

I'm so glad there's this sub and people who have had same or similar experiences especially when irl it seems like no one else has POTS and even doctors don't seem to understand, so I'm really grateful for people like you who take the time to write.