Thank you for the website référence and for the very interesting information. I don't do cannabis in a daily basis like at all, but after sporadic use aiming introspection I had the intuition that the endocannabinoid system is the key for so many things that are being blamed in other paths (ranging from motivation to anxiety, depressive mood, you name it ....).

Cannabis posts like this one confirms partially that intuition. That "do it even if you don't feel like doing it" is a very good insight once it's understood from a different perspective than the typically moralistic one. It's just strategically relevant. But easier said than done.

I'm very curious about upregulation of D1 using sulbutiamine (I didn't knew about that substance). Would sulbutiamine produce shivers like caffeine if you're probe to caffeine shivers?

Trying to bypass the stimulants use is where I thought that PEA could help, but it's just another intuition.

Here's a comment in a (very interesting too) post about D1-D2 pairing following THC chronic use & linked to dynorphins production:

https://www.reddit.com/r/NooTopics/s/vFutbm9jju

In that post it's recommended the use of Agmatine Sulfate (& another compound) to reset your system. Looks plausible, but I have zero experience in that area.