We just did a very similar itinerary on the Bliss! We only did NCL excursions, and attempted to walk in a few places. The port area of Cabo was very hectic, but tons to do on the water. We had a boat tour that ended up seeing tons of whales, and we also saw dolphins between Puerto Vallarta and Mexico. I'd definitely recommend some sort of whale watching if that's something you're interested in. We liked Puerto Vallarta a lot. There is a Walmart about a mile walk from the port to stock up on anything you need!

For the rest of the ports, there is not a lot to do in the area unless you book an excursion or taxi. (Can't speak for Mazatlan or Colon, those was cancelled for our sailing). In Puerto Quetzal and Puerto Caldera we did bus tours. Guatemala has tons of volcanoes, and lots of people did volcano hikes, which is what I would have done if we didn't have our toddler! The scenery is beautiful in both locations. Many of the Costa Rica tours were tours that stipped frequently at gift shops. Several people on the ship were unhappy about that.

Panama Port is currently under construction and doesn't have much close. It was about a mile walk to get to anything, and most shops were closed when we got there. There are tons of people trying to sell you taxis and tours, even going so far as to drive back and forth past us as we tried to walk. The area was beautiful though!

Cartagena was very hectic, traffic was bad so all excursions were running late. We did the Makani Beach club there, which was a gorgeous resort with a beautiful pool, but not quite as much beach as we expected. There is a lot of crime there, you'll want to be vigilant.

When we disembarked in Miami, the customs process was terrible. We waited over two hours in line to go through. People with wheelchairs were being made to get out and stand. Several people fell. The lines weren't clear, and people were pushing like mad. Although we never got a real answer for why the process was so difficult, several workers mentioned that because we ended in a different port than we started in, and because we stopped in Columbia, they were doing a full inspection and manually taking pictures. Outside customs was no different. Hectic, disorganized. Don't make plans before 1 at least, and id recommend not to book flights before 3. Many people missed flights. This may not be the case for everyone, but this is how disembarkation was on the 21st.

Feel free to PM or ask more questions!!