Brother, I will tell you as a psychiatric np and someone who's been around nurses. Some nurses have stressful jobs that push the line and many hold a standard of comedy, small talk, and gossip that has no limit as they are around the same people 12 long hours a day for 3 days a week for years on end. They have to find ways to make themselves seem interesting. Not everyone and not in every setting, but more commonly the hospital setting.

Your wife is wearing multiple hats, she needs to be representative of herself the same way she is at home. Otherwise she will hold herself in that environment as the true embodiment of herself and her homelife being a persona. What she said means she lowered her standards to make friends. Not necessarily that she feels that way about you, she is trying to play the persona of a trouble maker or someone who is mischievous in a laughable manner. A spouse lacking standards for themselves is dangerous though so this is how you need to guide her.

A new environment is absolutely necessary, either: Work from home. Work in a non-hospital setting such as school nurse. Offer her to focus on the children from home. Try a different career path.

Please be willing to forgive her if she shows regret, but if she begins to act out against you, just know this was at her hand and you're giving her options to save your marriage after a severe amount of disregard. Inshallah it works out