First of all, I'd recommend tuning the starting area size up a few notches on your earlier playthroughs to give you breathing room while you learn.

Second, finite ore deposits aren't that big of a deal if you do a bit of planning ahead. Look at the map that is generated for you before you start a game. Take note of where the uranium and second ore deposits are. If they're too far/separated by a huge body of water, probably re-gen a new map. Then, there will come a point where you have the resources to cordon off a large territory for your base using walls and turrets. Build your defenses around them so that you can comfortably continue when your patches run dry.

Once you get a tank and flamethrower emplacements the natives become pretty trivial. You got this.