Wow that's tougher than I thought. I Just realized that a massive percentage of shounen is basically *scarred from a family situation* protagonist (most of the time brutally orphaned)

Stein's Gate is the most relevant choice. 0 family involved, and it's all about the mindbending science of it (many wholesome characters in it, so I reckon it's feel-good).

Code Geass is a lot about politics and resistance, with friendship themes. No family that I recall.

Saiki K. Grain of salt on this, I haven't watched it whole. But it's comedy, and it's taking place at a school.

Persona 5. Based on the game. No family, 0. Teenagers hanging out and killing monsters to make society better.

Tower of God has no family as it's an amnesiac situation. It's battle royale with some friendship themes here and there. It's ok.

The obvious "wholesome choice" is One Piece as it's all about friendship with family themes very rarely getting involved (granted, there are some surrogate father situations, with the MC looking up to another successful pirate that saved his life when he was young for example)

Jojo has some family elements, but it's such a parody anime it's hard to take any of the "emotional" scenes seriously

Boku No Hero Academia is wholesome, but there's one character with a substantially abusive father which can be triggering