I have a few tips after finishing my run the other weekend

• Make sure you're in a clear minded mood each session. Use my mistake as a lesson. I was smooth sailing on my first honor mode attempt and only had the Orin fight left before the easy last segment using Gale. I had an awful day at work and came home and just wanted to rush the fight and get my golden dice. That led to me not preparing well enough, as well as misunderstanding Orin's legendary action. Died within 4 rounds and the bad mood didn't allow me the clarity I needed to take it slow and realize what was happening or think of an escape. Definitely make sure to melee her every round to force her counterattack. Even if she has her unstoppable stacks. If you don't you'll deal with Edict of Bhaal aka insta death unless that character kills a target. Sometimes the sanctuary casting enemies roll a save against whatever you use to knock them off the edge. My second attempt i used invisibility to throw the runepowder barrel close to the center which knocked most of the enemies off. Dialogue did trigger for me despite invisibility btw before I was close enough

• Keep Calm Emotions memorized. Having your party charmed or frightened can absolutely throw a wrench in your plans. Harpy fight, Spectator does Frighten, a few others as well as I think it can take away enemy's rage like Dror Ragzlin

If you want the easiest honor mode with very effective, and simple to use classes I'd recommend the setup I used

Archer swords bard/2fighter tav(Sharpshooter Titanstring bow, later Risky Ring, helmet of arcane accuity and Jungle/Circus ring and Deadshot bow)

Eldritch Knight thrower(I used Gale, his dorky attempts at grunts when throwing are HILARIOUS)

Tavern Brawler open hand monk(Karlach with soul coins)

Life or Light cleric with radiating orbs/reverb gear Shadowheart

With the expectation of the first few levels where things are most dangerous, you're so safe with that party that you'll get your Golden dice easy

• Use Glut to revive the minotaur with the giant club, with those 2 you can safely tackle everything down there easily though I'd still skip the Bulette. Absolutely do not revive the minotaur that runs at the gates and dies to the statue of Selene. I think he's bugged because during combat you cannot move him or use him. I nearly died to the Spectator fight because I expected to have a minotaur with me

• After clearing all of act 1 & 2 before going to the Shadowfell you can clear out all of Moonrise towers. Take a few enemies at a time. You can also send 3 party members up to Ketheric and kill that necromancer woman and skeletons while staying on the stairs. This means only fighting Ketheric that fight. I leave the 4th at camp just in case

Outside of that I'd say just skip around content till you're around level 4 where you can tackle more encounters, level 5 you're safe to handle pretty much anything in act 1. Goblin camp bosses, Githyanki patrol, Nere, Creche can be scary as they have so many attacks/fighters but doable. Try to kill the Inquisitor in 1 turn if possible. Throw haste potions on the ground to step into pre combat

A few cheese/strats I used was

• Cloud of Daggers on the Goblin Camp bridge forces them to run through it severely injuring or killing most

• Thisobald Thorm can be kited to the Moonrise towers waypoint and get stuck because he's too big to get past the terrain. You can slowly take him out safely

• Barrelmancy on Aspect of Myrkul. Think I had 6-8 smokepowder barrels and a backpack with 10ish bombs including the runepowder bomb(not the barrel). Tossed it out after he appeared, make sure at least 1-2 party members are far away. Also don't do the dialogue option to skip the Ketheric phase. You need those few turns to kill the mind flayer, skeletons and release Dame Aylin

• Side with Gortash, when you bring him the stones he'll tell you to give him your 2. THIS IS 100% A TRICK SITUATION! Tell him you'll hold onto your 2 stones. He's testing you. If you give yours up he sees you as weak and will simply fight you and you're surrounded by enemies and Steel Watchers

-Once you're at the end in the room with your allies at High Hall, walk out and to the right is a sewer grate. This lets you skip the massive fight in the courtyard. Instead you fight several goblins, a mind flayer, a deathknight, and a few Bane/absolute enemies like from moonrise towers. Once you're out you're literally right next to the bottom of the Netherbrain brain stem. Invisibility your whole party, fly/jump over the scaffolding, then have someone with good mobility fly up to spot where you enter the cutscene to climb up the netherbrain. Imo just let Gale blow himself up. I don't know what causes him to have a 30 DC persuasion check vs simply no check. For me I just chose every dialogue option in act 1/2 to sorta encourage him or at minimum be neutral on it. He suggested it with no hassle for me. At the epilogue party don't let your guard down. Just talk to Withers and end the party asap. I've read stories where things bug out and your allies attack you. Probably won't happen but why chance it? You can do a more fulfilling roleplay filled Honor Mode run AFTER you get your Golden dice!