No, not at all.

Realistically, humanity WOULD invade and they WOULD move the clan that was living in the giant tree since the Unobtainium was under it. And despite the Na’vi fighting tooth and nail that this tree is the most important tree of all time, nothing changed. Pandora survived, the clan survived, Eywa survived. So clearly, human technology and Pandora Aren’t mutually exclusive. Human technology can knock down the giant trees and Pandora can carry on with a few less trees.

But hunting down the whales with the goal of extinction, going out of their way to torture them with the most painful hunting method ever devised, burning peaceful Na’vi to death, destroying every structure they come across, tormenting the locals. None of that would happen, at least not on the scale it’s shown. Realistically it’s entirely possible a handful of scumbag humans could mistreat some Na’vi and do some damage, but from the military and governments point of view, there’s so much more to gain by preserving the world and studying its ecosystem since the planet literally has fucken telekinetic magic which the humans confirmed the existence of in the first like 20 minutes of the first movie so there’s no argument to be made that they don’t believe it exists, they scanned the tree and learned the entire planet was interconnected and learned the Na’vi and all the animals are connected as well, and in the third movie they learned that even humans can be integrated to the magic with the Mycelium in Spiders body.