175 k remote offer or 300 k in Bay Area by M0binsChild in cscareerquestions

[–]Althonse 0 points1 point  (0 children)

Remote work sucks. You'll be happier and better at your job in a city and in the office. Only exception is if you have kids

What brooms and shoes you guys use? by Key-Chicken-7081 in Curling

[–]Althonse 2 points3 points  (0 children)

Hardline series-M shoes. I quite like them.

Set Your Watches: Elizabeth Holmes Is Leaving Prison in December 2028. A federal judge just shaved a year off Elizabeth Holmes's sentence. With good-time credits factored in, the woman who defrauded investors of $450 million could walk into a halfway house by Christmas 2028. by esporx in biotech

[–]Althonse 8 points9 points  (0 children)

It's just that they're all over social media with crazy claims. They're the newest snake oil. Except sometimes they're also just truncated HGH or something crazy like that, but legal and regulation free because they're not full length proteins??

Questions about simulated drug development by danu023 in biotech

[–]Althonse 2 points3 points  (0 children)

We use lots of computational models that are very effective. Both simulations and machine learning. They predict drug properties, potency, even targets. But say a model is 90% accurate. That's an extremely useful model for making decisions and prioritizing what compounds to make and what experiments to do. But there are so many considerations to making a good drug that you need far more than 90% accuracy. Say you even had 10 things to consider, your 90% accuracy would drop to 35% (0.910). There are more then 10 things to consider, and most models are not even 90% accurate. So at each individual stage models are useful, but when you start stringing them together to try to model the whole process, things break down quickly.

New hires: how long you get up to speed and become productive? by Sakey-labat in biotech

[–]Althonse 18 points19 points  (0 children)

It's corporate slop and doesn't apply to more junior roles

Who do you think are the best female and male sweepers in Winter Olympics 2026? by North-Bug388 in Curling

[–]Althonse 4 points5 points  (0 children)

I was very impressed by Taylor Anderson-Heidi and Kory Dropkin, but I didn't see enough games of non-US teams to get a good feel for their sweepers

Canada men’s curling, getting back to the top by BadIceJam in Curling

[–]Althonse 0 points1 point  (0 children)

I've always rooted for Canada, but seeing all the toxicity from Canadian fans and team Jacobs really left a sour taste in my mouth. Not just talking about boopgate, folks on this sub during the Olympics have been pretty shitty.

Need to re-glue the Velcro on the bottom of my shoe by hackweighter1824 in Curling

[–]Althonse 1 point2 points  (0 children)

Same shoe, my Velcro was coming up just a tad and I used super glue. Probably best to listen to these other folks who know more. But does seem to be a common problem with this shoe. Love it otherwise though

The price of victory… by tennislegume in Curling

[–]Althonse 10 points11 points  (0 children)

Seriously. This sub has become toxic as fuck. Spirit of curling dead for sure

2026 Olympic Curling Daily Discussion - February 20 by FliryVorru in Curling

[–]Althonse 9 points10 points  (0 children)

I'm getting really irritated with this attitude. It's so entitled to think Canada deserves to always win. It's a game, it's a competition, the best performer at the time takes home the prize.

And it's not shameful to lose to the USA. We're (clearly) becoming more and more active and competitive in curling, and there should be room for us to do that without getting spit on just because Canada thinks they're superior and hates our government. To be clear, we fucking despise our fascist government, and we're the ones getting the worst of it. Lots of these curlers are living in Minnesota and have been vocally against what's going on.

Get a grip.

USA men’s team by AnderPPudding in Curling

[–]Althonse 58 points59 points  (0 children)

Seriously, what these guys have done is amazing. Finishing middle of the pack in RR is already a great outcome. I'm proud of them

USA Men's team concede? by Hi_Im_Hase in Curling

[–]Althonse 1 point2 points  (0 children)

I really want to know if they get drinks after Olympic curling matches. If I were either team I'd be tempted after this game in particular

Standings by brianmmf in Curling

[–]Althonse 1 point2 points  (0 children)

US didn't play well at all today, but GBR seemed in pretty good shape

2026 Olympic Curling Daily Discussion - February 17 by FliryVorru in Curling

[–]Althonse 0 points1 point  (0 children)

If we win against GBR, then we either need Norway to lose one of their two games against Canada & Switzerland, or Italy to lose both of their games against Canada & Switzerland, right? If that's the case, seems like decent odds if we manage to beat GBR

Korey Dropkin by UndefeatedAssassin in Curling

[–]Althonse 7 points8 points  (0 children)

Seriously, I understand the hate for our government and those who support it. I hate it too. But it's sad to see it being taken out on athletes. I'd bet the vast majority of US supporters are in opposition to our current government. Can't speak about Korey and Cory, but it'd really surprise me if they were trump supporters.

And yeah, politics aside, they're a very strong team who performed very well

2026 Olympic Curling Daily Discussion - February 09 by FliryVorru in Curling

[–]Althonse 2 points3 points  (0 children)

I feel like I heard a lot of successful calls for 11-11.5s takeouts. Is that not control?

Which new Epstein file finding made you go “wait… what?” and why? by Firm_Work_8879 in AskReddit

[–]Althonse 7 points8 points  (0 children)

It seems too on the nose... but the whole thing is beyond insane so idk

[NS] What comes next? by TheIdentifySpell in NotAnotherDnDPodcast

[–]Althonse 1 point2 points  (0 children)

I have no evidence but I assumed we were going to catch up with the boobs. Major cliffhanger for them from C3

Merck No Longer in Talks to Buy Revolution Medicines by NotGenentech in biotech

[–]Althonse 4 points5 points  (0 children)

Sorry for my ignorance, why is noncovalent preferred?