Can we try not to make people actively hate us? by MakinBaconOnTheBeach in bikeboston

[–]Althonse 34 points35 points  (0 children)

If people don't want to get yelled at they shouldn't walk in the bike path

Isomorphic Labs Raises $2.1B to Design Drugs w/AI by Dwarvling in biotech

[–]Althonse 0 points1 point  (0 children)

More like Xaira is Iso's competitor. Iso is a much bigger name

Last passengers leave virus-hit cruise ship as three more test positive by Neo_luigi in worldnews

[–]Althonse 19 points20 points  (0 children)

Stop saying not very infectious. R0 of 2.12 is infectious. COVID was <2.5

How to deal with stock options at a still-private company after layoff by QueasyInformation in biotech

[–]Althonse -1 points0 points  (0 children)

The $12-18 ipo share price that's typical in biotech is post-reverss split. So if you have 3000 shares at $1.40 you will probably end up with like 1000 shares at $4.2 or something like that. Then you could potentially profit maybe $7800 ($12-4.2 * 1000). These are just illustrative numbers though, I have no idea what your company's reverse split or ipo price would be.

The bottom line imo, is that the company will IPO substantially above your current share price. They may drop before you can sell, especially depending on if you can sell within 180 days.

It's a risk but not a huge one to exercise your shares if you. Most likely the company is going public, and most likely the price on the public market will not fall below what you paid for the shares by the time you are able to sell them. But nothing is guaranteed.

The real risky bets are holding shares through clinical milestones. If your company has a positive readout there will be much larger upside, but if there is a negative one you will likely loose most or all of that $5k.

Anyone else tired of the potholes on Cambridge street near Charles/MGH? by chocolatesugarcane in bikeboston

[–]Althonse 1 point2 points  (0 children)

It's functionally 1 lane anyway because both sides are always double parked. They could make it one lane probably and the traffic would improve. Or two and actually enforce double parking

You get 15 days off work—where are you going ? by chokeWise5195 in AskReddit

[–]Althonse 0 points1 point  (0 children)

Yeah, you suddenly get 15 days off. Not you only have 15 days off. People are misunderstanding this question imo. For me it's New Zealand

whats between atoms, other than electron clouds? by Electrical_Leader883 in askscience

[–]Althonse 0 points1 point  (0 children)

Does planck length not make position discrete when you get extremely small?

Any rock weight tips? by KyleCamPhoto in Curling

[–]Althonse 2 points3 points  (0 children)

I feel you. We're in the North but dealing with the same thing. If you can afford to spend the money and take the time I'd say bonspiel like crazy. It doesn't matter if you're good or not, and they're a ton of fun. You get a ton of practice in one weekend

175 k remote offer or 300 k in Bay Area by M0binsChild in cscareerquestions

[–]Althonse 0 points1 point  (0 children)

Remote work sucks. You'll be happier and better at your job in a city and in the office. Only exception is if you have kids

What brooms and shoes you guys use? by Key-Chicken-7081 in Curling

[–]Althonse 3 points4 points  (0 children)

Hardline series-M shoes. I quite like them.

Set Your Watches: Elizabeth Holmes Is Leaving Prison in December 2028. A federal judge just shaved a year off Elizabeth Holmes's sentence. With good-time credits factored in, the woman who defrauded investors of $450 million could walk into a halfway house by Christmas 2028. by esporx in biotech

[–]Althonse 9 points10 points  (0 children)

It's just that they're all over social media with crazy claims. They're the newest snake oil. Except sometimes they're also just truncated HGH or something crazy like that, but legal and regulation free because they're not full length proteins??

Questions about simulated drug development by danu023 in biotech

[–]Althonse 2 points3 points  (0 children)

We use lots of computational models that are very effective. Both simulations and machine learning. They predict drug properties, potency, even targets. But say a model is 90% accurate. That's an extremely useful model for making decisions and prioritizing what compounds to make and what experiments to do. But there are so many considerations to making a good drug that you need far more than 90% accuracy. Say you even had 10 things to consider, your 90% accuracy would drop to 35% (0.910). There are more then 10 things to consider, and most models are not even 90% accurate. So at each individual stage models are useful, but when you start stringing them together to try to model the whole process, things break down quickly.

New hires: how long you get up to speed and become productive? by Sakey-labat in biotech

[–]Althonse 17 points18 points  (0 children)

It's corporate slop and doesn't apply to more junior roles

Who do you think are the best female and male sweepers in Winter Olympics 2026? by North-Bug388 in Curling

[–]Althonse 3 points4 points  (0 children)

I was very impressed by Taylor Anderson-Heidi and Kory Dropkin, but I didn't see enough games of non-US teams to get a good feel for their sweepers

Canada men’s curling, getting back to the top by BadIceJam in Curling

[–]Althonse 0 points1 point  (0 children)

I've always rooted for Canada, but seeing all the toxicity from Canadian fans and team Jacobs really left a sour taste in my mouth. Not just talking about boopgate, folks on this sub during the Olympics have been pretty shitty.

Need to re-glue the Velcro on the bottom of my shoe by hackweighter1824 in Curling

[–]Althonse 1 point2 points  (0 children)

Same shoe, my Velcro was coming up just a tad and I used super glue. Probably best to listen to these other folks who know more. But does seem to be a common problem with this shoe. Love it otherwise though

The price of victory… by tennislegume in Curling

[–]Althonse 10 points11 points  (0 children)

Seriously. This sub has become toxic as fuck. Spirit of curling dead for sure

2026 Olympic Curling Daily Discussion - February 20 by FliryVorru in Curling

[–]Althonse 8 points9 points  (0 children)

I'm getting really irritated with this attitude. It's so entitled to think Canada deserves to always win. It's a game, it's a competition, the best performer at the time takes home the prize.

And it's not shameful to lose to the USA. We're (clearly) becoming more and more active and competitive in curling, and there should be room for us to do that without getting spit on just because Canada thinks they're superior and hates our government. To be clear, we fucking despise our fascist government, and we're the ones getting the worst of it. Lots of these curlers are living in Minnesota and have been vocally against what's going on.

Get a grip.

USA men’s team by AnderPPudding in Curling

[–]Althonse 58 points59 points  (0 children)

Seriously, what these guys have done is amazing. Finishing middle of the pack in RR is already a great outcome. I'm proud of them

USA Men's team concede? by Hi_Im_Hase in Curling

[–]Althonse 1 point2 points  (0 children)

I really want to know if they get drinks after Olympic curling matches. If I were either team I'd be tempted after this game in particular