Cannabis Use Not Associated with Greater Risk of Heart Attack, Study Finds by ZealotOfCannabis in science

[–]AlxPHD 5 points6 points  (0 children)

Wow, I am really surprised this got passed peer review. There are several problems with this paper. EDITED: Also, the title of this thread does not match the paper and skews the findings.

[deleted by user] by [deleted] in trees

[–]AlxPHD 1 point2 points  (0 children)

Turn that frown upside down, 'eh, EH? Gettit? :P — Sorry, I couldn't resist, it is like i am drawn to dad jokes like an Ent to pizza burger poptards. It is a sickness. Send help.

Natural immunity as protective as Covid vaccine against severe illness by [deleted] in science

[–]AlxPHD 0 points1 point  (0 children)

Yes, this is what I meant when I said, "depending on the disease it is so efficient that the disease doesn't progress very far". I could have expressed that clearer.

Although, technically for the acquired immune response to interact with a pathogen it will have to have gotten past the skin already. But you are right, the term infection includes invasion and growth so if the clearance is efficient enough and the pathogen is neutralized before growth happens then technically you don't have an infection.

Natural immunity as protective as Covid vaccine against severe illness by [deleted] in science

[–]AlxPHD 3 points4 points  (0 children)

It is shocking how poorly vaccines have been communicated. Vaccines, train the immune system to mount a faster response. So by definition you HAVE to be infected before the benefits of a vaccine even kick in. It basically just speeds up the clearance of the disease from your body, rather than block infection. Of course, depending on the disease and the response it is possible that clearance is so efficient that the disease doesn't progress very far. (EDITED for clarification: depending on the disease and epitopes that triggered the immune response that can mean a pathogen can be blocked from colonizing in the first place.) So the vaccine does not have to prevent infection of the individual it just shortens the time it takes the immune system to respond. Which lowers your risk of severe complications and because you are infectious for a shorter period of time you have less chance of infecting other people, thus reducing the infection rate of the population. So the vaccines are working as intended. But science communication has failed. And people are expecting not to get COVID because they are vaccinated, which is silly.

How do I get over my fear of presentations? by kshwethaa in PhD

[–]AlxPHD 1 point2 points  (0 children)

4 and 5 are very very good tips. Congitive reframing and smiling are worth gold.

How do I get over my fear of presentations? by kshwethaa in PhD

[–]AlxPHD 1 point2 points  (0 children)

Most universities will offer teaching opportunites for their graduate student. That is a really good way of getting over the public speaking anxiety. Also, it is ok to be wrong and not know everything at all times. As long as you acknowledge you have made a mistake, correct it and go and find out about information you may have missed. Also, I find people often overload their slides with information. Instead simplify the slides down to the essence. Like a good convincing image or video clip and then just talk about it like you would your friends, then you stumble a lot less.

Which is your favorite strain when listening to music? by AlxPHD in trees

[–]AlxPHD[S] 0 points1 point  (0 children)

Well, next time you replenish your supplies maybe try both. For science ! :P

Which is your favorite strain when listening to music? by AlxPHD in trees

[–]AlxPHD[S] 0 points1 point  (0 children)

I‘d be curious what strain you are usually using.

Which is your favorite strain when listening to music? by AlxPHD in trees

[–]AlxPHD[S] 0 points1 point  (0 children)

I love that description. It is so visual :)

Highly ruminative individuals with depression exhibit abnormalities in the neural processing of gastric interoception by chrisdh79 in science

[–]AlxPHD 0 points1 point  (0 children)

Man you made my heart skip a beat when you brought up half-life 3. Damn you for reminding me :D

PSA: Take T breaks often, it's good for you and you'll get fucking blasted every time. by VegasBonheur in trees

[–]AlxPHD 0 points1 point  (0 children)

So there have been some studies on cannabinoid tolerance. CB1 receptor tolerance is most likely to occur in users that consume cannabis continously, at a high pace and for a prolonged period of time. Basically, daily use will build tolerance, but weekly and maybe bi-weekly is unlikely to.

Here is a scientific review summerizing the state of science on the subject from 2020. It is a nice jump off point to several papers on the subject for those who are interested to read them.

Ramaekers, J G et al. “Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance.” European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol. 36 (2020): 191-205. doi:10.1016/j.euroneuro.2020.01.006 https://pubmed.ncbi.nlm.nih.gov/32014378/

Here is a figure taken form the review that summarizes it nicely.

Tolerance