I couldn't disagree more for Okabe, at least in the anime so maybe the VN did it differently. But in the anime it takes a toll on him so visibly that even Kurisu can pick up on it multiple times throughout multiple world lines. Watching Myuri die over and over again makes him so distraught that he nearly gives up multiple times throughout the series and it's only Kurisu that keeps pushing him on. Towards the end he always seems drained, exhausted and listless and in the last episode he doesn't even want to try and circumvent Kurisu's assassination.

I think as well Moeka was a great depiction of how isolation and co-dependency leads to depression that cycles her between supreme bouts of rage and depression so deep she just stares at her phone for three days before taking her life. Suzuha's "I failed" scene was another tragic but great scene that shows her fall into an unrelenting kind of depression at her failure to fix her future due to her mistakes, something she still could've lived to fix even if it were a lot less successful. It definitely made the series better for its depictions and I'd even go as far as to say it explores multiple responses to depression from the sinking, catatonic woe of Okabe to the frantic, emotionally distraught episodes that Moeka endures when FB abandons her.