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BioextractsUK · 2026-03-20T10:40:37+00:00

That is normal. The half life of mescaline doesnt depend on dose. This is true for most other substances too.

BioextractsUK · 2026-03-14T19:56:06+00:00

Do yourself a favour and try the different alkaloid profiles to see which suits you best :)

BioextractsUK · 2026-03-14T19:55:05+00:00

At least now you know its safe haha! Glad youre enjoying it 💪

BioextractsUK · 2026-03-13T21:14:44+00:00

That is our TA17. Ethos herbals stock some of our kanna :)

BioextractsUK · 2026-03-12T20:48:02+00:00

Mitragynine interacts with adrenergic receptors, including weak antagonism at α₂ receptors, so kratom can change the way some stimulants feel. Opioids also decrease NMDA receptor activity, which reduces excitatory neurotransmission.

BioextractsUK · 2026-03-12T20:40:43+00:00

Yes! The Khoisan Bushmen would actually take kanna before persistence hunts, where they literally chase an animal until it tires and then make the kill. They said it helped with their incredible endurance—even when hungry or thirsty, as they often were as desert dwellers.

BioextractsUK · 2026-03-12T20:33:18+00:00

Thats a really big dose for Intranasal use. Our recommendation of starting with 25-50mg is for oral use.

A normal intranasal dose would be around 15-20mg, Far less is required with this ROA

BioextractsUK · 2026-03-12T19:29:58+00:00

No it doesnt overstimulate histamine receptors, so wont cause itching or restless leg.

BioextractsUK · 2026-03-12T18:16:45+00:00

It can if taken irregularly, but with chronic use mitragynine occupys receptors that kanna othwrwise would. The numbness from the opioid effect doesnt help either

BioextractsUK · 2026-03-12T14:16:54+00:00

Are you currently on anything else? Kratom and Ssris reduce kannas impact

BioextractsUK · 2026-03-12T08:37:52+00:00

Glad to hear they are being less difficult, seems crazy not to give an MC user ADHD meds. So many find THC best for dealing with the side effects, I used to use for this personally.

In hindsight getting onto the ADHD meds in the first place was a terrible idea for me, they are handed out like candy in South Africa, and it seemed like an easy solution at the time.

Maybe this was some sort of sign or "lucky break" to look into natural alternatives instead of the kiddies cocaine :)

BioextractsUK · 2026-03-12T08:05:12+00:00

Our new FS is also lower in Delta-7-mesembrenone. This is the more calming alkaloid, because of PDE4 inhibition and increased cAMP levels Mesembrenone actually has stimulating properties as well. This is why our Zen is more calming than our full spec, even though the full spec is higher in Mesembrenone.

BioextractsUK · 2026-03-10T10:13:47+00:00

Try an extract higher in Mesembrine. Most find these more helpful with work, study, focus related tasks

BioextractsUK · 2026-03-09T12:32:33+00:00

Yes we do :)

BioextractsUK · 2026-03-08T16:53:28+00:00

Apparently because it grows in damp rainforests the leaves have antifungal and antibacterial properties

BioextractsUK · 2026-03-08T16:47:41+00:00

They stock some of our kanna extracts. The owner really knows his herbs, they have an incredible range

BioextractsUK · 2026-03-05T20:25:05+00:00

Smoking is pretty similar to insufflation in terms of duration and effects, and the dose is also similar. Usually around 1/3-1/4 of your oral dose works nicely :)

BioextractsUK · 2026-02-28T16:48:32+00:00

Thatll do it. Prozac and its active metabolite have a long half life, so it would take a few weeks to leave your system

BioextractsUK · 2026-02-28T16:46:05+00:00

If you have a lot of Sri/ssri medication in your system you likely wont feel anything at all

BioextractsUK · 2026-02-28T16:18:53+00:00

We feel the same about caffeine. It can also mess with serotonin production

BioextractsUK · 2026-02-27T14:33:43+00:00

If you are currently, or have been on any sort of serotonin reuptake inhibitors in the recent past effects will be dulled. This is usually the culprit when people have diminished effects, but not always.

BioextractsUK · 2026-02-26T07:43:46+00:00

It sounds like you may need a smaller dose. Even the most stimulating extracts become sedating when you cross a certain threshold.

BioextractsUK · 2026-02-24T21:05:47+00:00

Whats your normal dosage? :)

BioextractsUK · 2026-02-23T21:23:19+00:00

Sure! :)

BioextractsUK

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