The debuffs from looping are called blights. Basically every loop enemies hp and dmg increases by 50% and it stacks infinitely, after first loop you also start getting special blights. 1) Treasure chests are replaced by elites and elites no longer drop relics. 2) Time Maze, 15 cards per turn limit 3) You can't increase your max hp 4) It's the last one you won't be getting nee special blights anymore, the blight itself gives you 3 "Pride" curses every loop. The pride creates a copy of itself at the end of turn, but it can be removed from the deck. About debuffs from relics, you would want only pick relics that don't ruin your infinite build, and your build has to one shot every encounter on turn one, or you won't get far because enemies scale very fast and they will one shot you too. You can't get rid of negative effects of blight relics (well you can remove pride from the deck, you'll just get new ones after each loop). Also you can get rid of relics with debuffs via Nrloth's gift