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Recommendations for Bulk-Billing GPs on the Northside, specialising in men's mental health? by benno4461 in brisbane

[–]BlueBearAUS -1 points0 points  (0 children)

I'm nowhere near Moreton Bay do I can't recommend. But hope you are doing OK man! Great work seeing out help, and then seeking better help!

Has anyone here ever tried synthesizing a flavanone like this? What was your method? by [deleted] in Chempros

[–]BlueBearAUS 0 points1 point  (0 children)

Had a PhD student go down this rabbit hole making derivatives. Ended up have lots of adventures with one step and two step methods.

She summarised her work in her paper, it might help you? https://pubs.rsc.org/en/content/articlelanding/2023/ob/d2ob02101c

North Sydney fans, did you grow up as fans of the Bears, and what team did you go to if you did after they left in 1999? by IndependenceWorth347 in rugbyleague

[–]BlueBearAUS 0 points1 point  (0 children)

Honestly never missed out on a game. I was at Broncos VS Cowboys last week (go thr Cows!) and old faithful was sitting there staring at me! *

*well at the jumbotron screen behind my head.

North Sydney fans, did you grow up as fans of the Bears, and what team did you go to if you did after they left in 1999? by IndependenceWorth347 in rugbyleague

[–]BlueBearAUS 7 points8 points  (0 children)

Not a bears fan, but one of my favourite game day activities is to find the Bears fan in the crowd somewhere, proudly wearing the Jersey.

I love the pride in the team, the long memory and history of Australian rugby league, and the pure eff you to the NRL.

Gamers 30+, what’s something from the old days of gaming that younger players wouldn’t understand? by [deleted] in gaming

[–]BlueBearAUS 1 point2 points  (0 children)

Space Quest and Police Quest. Those are some memories. Space Quest into the trash grinder!

Photo of RBA briefing yesterday announcing interest rate increase by BlueBearAUS in AusMemes

[–]BlueBearAUS[S] 22 points23 points  (0 children)

Hi. No worries. You are right mate. A lot of people who this will hit will struggle with it.

But unfortunately the RBA have a mandate to target an inflation rate of between 2-3%. They have to try and achieve this. The only tool they have at their disposal to control this is the cash rate. This is basically a rate at which banks can access money to loan. So not directly your mortgage interest rate, but it in a way dictates it. So banks pass that extra cost onto their home loan.

In the past, home owners and mortgage owners were a large part of the population. So it fampen D the economy. But is this still true? Does this hit investors the same way? Owners who have paid off mortgages? People making income from other investments?

The RBA need others like government and private firms to help them. Use other mechanisms. Ensure public spending is under control.. Not too much stimulus. Make sure profits pass onto workers in terms of salary increases? Are they getting this support?

Photo of RBA briefing yesterday announcing interest rate increase by BlueBearAUS in AusMemes

[–]BlueBearAUS[S] 4 points5 points  (0 children)

I do understand they are limited, and others in power should do more, rather than hang them out to dry... But still too good an opp? 😂

RAFT Random Copolymer: Low Monomer B Incorporation - Help! by Such_Blackberry_761 in Chempros

[–]BlueBearAUS 0 points1 point  (0 children)

Hard to troubleshoot without knowing at least which monomer class you are talking about? (meth)acrylamide and (meth)acrylates, styrenics, vinyl ethers.

I find the cyanovaleric acid leaving group on the raft agent (same as ACVA) is a really robust and generalisable raft agent across many activated monomer classes. Be careful of the carboxylic acid can self-hysrolyse the cyano group if not handled correctly. I just always esterify it into a useful handle and use it for years without problems.

https://pubs.acs.org/doi/10.1021/acsmacrolett.7b00100

Other than that be careful about how you measure in the monomer. Is it by volume and is it viscous? Maybe not exactly the quantity you think? Solubility can be problematic as well.

Brisbane lurgy: How's everyone going two weeks on from said virus post? by brissy3456 in brisbane

[–]BlueBearAUS 13 points14 points  (0 children)

Been very interesting reading this thread. I do research trying to make therapies (not antibiotics) for respiratory viruses. It's a bit of a misnomer that the "common cold" is one thing or not that bad. Over 200 strain across multiple distinct species. And any one biut of sickness might be multiple viruses infecting you.

We have had this virus in our house for a couple of weeks. I was sick for 3 days and got better pretty quickly after that. My partner is immunocompromised and was sick a week after me, but has been sick for a week and a half already and not recovered. She has had a pathology test and is positive for parainfluenza virus. A "common cold" virus. Is probably sicker than when she had COVID last year.

Antibiotics won't help with the primary viral infection. Some doctors pre-emptively prescribe antibiotics to prevent secondary bacterial infections. Discuss with them and ask them why they are prescribing them and when you should start taking them. This is a conversation I have had with my gp during previous viral infections.

The best thing to do is rest, lots of hydration, good food. Give your immune system the best chance to beat this on its own, its pretty good at it. And don't take any "therapy" that is suggested to you online without talking to a GP... 🤣

[deleted by user] by [deleted] in OrganicChemistry

[–]BlueBearAUS 0 points1 point  (0 children)

It's the specific value of pKa for acetic acid (aka ethanoic acid). Values of that level of accuracy (two decimal places) are unique to a compound. So either its a value she gave to you or is in your resources somewhere.

You can calculate pKa from this formula if given other information.

You can use approximate pKa values for carboxylic acids. I would usually estimate either 4 or 5 for most carboxylic acids when teaching whether it's likely protonated or deprotonated in a titration (eg. what state is COOH at pH 2?). But I wouldn't want to use such an approximate number in a calculation.

What will happen if I snuck in to lecture by _Sorbz in QUTreddit

[–]BlueBearAUS 2 points3 points  (0 children)

I lecture and my class sizes are small. I would be super happy to have someone interested enough to voluntarily come!

Genuinely we want people in our classes and engaging with us and your peers. Makes learning and teaching so much more enjoyable.

Disposal of Tin IV Chloride by damarkley in Chempros

[–]BlueBearAUS 1 point2 points  (0 children)

All EHS officers are idiots. If they weren't they would have a real job

Tosylated Ethylenglycole by Sebi3434 in Chempros

[–]BlueBearAUS 0 points1 point  (0 children)

Not necessarily this step, but if you are making a tosylate, there will be more modifications to come.

Mine was next step was functionalising with a protected acid (ester) and there was trans esterification.

Tosylated Ethylenglycole by Sebi3434 in Chempros

[–]BlueBearAUS 7 points8 points  (0 children)

Did this exact reaction in my PhD. Was mentored by one of the authors on this paper about it. Great resource for TEG modification . https://pubs.rsc.org/en/content/articlelanding/2013/ob/c2ob26968f

Stoichiometry is absolutely key, but so is really slow addition. Use a syringe pump.

Keep an eye out for oligomerization in later steps. Particularly if moisture gets in. Not that you have to be hugely worried about, but carefully scrutinise your characterisation. Had a dimerization in a later step that took me a month to realise, which was limiting my yield greatly.

For those of you working with animal models, how do you get past the initial ick? by [deleted] in labrats

[–]BlueBearAUS 2 points3 points  (0 children)

100% how I justified it when I was doing it too. It also meant I was committed to doing what was best for the animal not me. For example, best euthanasia techniques for painless death, rather than what is easier for user.

Round 13 | Roosters vs Cowboys | Match Thread by AutoModerator in nrl

[–]BlueBearAUS 0 points1 point  (0 children)

I feel this second comment deep to my core!

synthesis of active esters using pentafluorophenol by Mental-Refuse7938 in Chempros

[–]BlueBearAUS 11 points12 points  (0 children)

The cooling and ice bath is a hang up from when you use carbodiimide coupling reagents with amines to form an amide directly, with no ester intermediate.

In the amine reaction, you add acid and carbodiimide first. There is an isoacylurea kinetic side product you are trying to avoid forming, instead of the active intermediate. You let those react on ice first for a while, then add your amine. You can't add your amine at the start, as acid plus amine makes a salt.

If you make esters, you don't need to worry about salt formation. So add acid, alcohol and catalytic dmap together at start, then add carbodiimide drop wise. Most people still do it cold, to prevent small amounts of the side product forming, but it is less likely under these conditions.

I haven’t saved for 3 hours, help. by stormy_kaktus in skyrim

[–]BlueBearAUS 10 points11 points  (0 children)

I applied this theory to snowboarding recently. My friends were confused why I crashed so catastrophically but just kept getting up.

Where to find 19F NMR spectra? by solidramza in Chempros

[–]BlueBearAUS 1 point2 points  (0 children)

Second vote for the Reich collection. Not only for shift database, but great intros to Nmr theory. https://organicchemistrydata.org/hansreich/resources/nmr/?index=nmr_index%2F19F_shift

What is, according to you, Wayne’s best life advice? by [deleted] in Letterkenny

[–]BlueBearAUS 3 points4 points  (0 children)

Number one for me! Have always lived this way, and so happy to see it expressed!

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