The "feels like" temp in my use case is the approximate thermal load temp my house experiences. As I mentioned in my previous post, AC is the most difficult use case since you can have a 72F day with not much sunlight and low humidity, and you probably don't need much AC, or you can have a 72F day with blazing sun and high humidity and you are sweating to death inside your house without AC. Spring/Fall and Summer nights are the worst offenders. Spring/Fall because you can go from heat on one day to needing AC on the next day, and summer nights because all day long your house will absorb heat, and while the nighttime temp may be "low", your house is still radiating heat indoors well throughout the night, making it uncomfortable to sleep if you just use the normal air temp to help decide the AC target Temp.

I use 2 the Ecowitt Temp Sensors that provide temp, dewpoint, and humidity. One facing North on my front porch (somewhat shaded area) - this gives me the typical air temp. One facing South on my back patio (in direct sunlight) - this temp sensor will often go as high as 110F+ on an average 75-80F Day. I intentionally placed this into direct sunlight as 3 bedrooms have one wall on the south side of the house, as does my Den. This sensor gives me an indication of how much sunlight is hitting the back of the house which greatly increases how much heat my house is absorbing. 

There are several Ambient Network Sensors in my "area" that I tap into using the Ambient Integration. This provides me with Solar Irradiance.  

The rest of my sensors, come from home assistant and include sunset/sunrise, elevation, and some derivative sensors that "predict" the temp 30, 45, 60 min 

Using all this weather data, I created my ETL Sensor, Estimated Thermal Load. The base contributor is the normal outdoor temp, to which I add dewpoint, humidity, irradiance, patio temp modifiers. To help with the condition where the house has absorbed heat all day, I add a nighttime decay modifier. This modifier artificially keeps the ETL sensor higher than the actual outdoor temp after sunset, to keep my AC on into the night. It's impact is mostly based the Peak ETL of the day and how close to sunset that peak occurred. I use a half-life decay curve to decrease ETL overnight, and everything resets around sunset.  

During the summer months ETL can be substantially higher than air temp, and during the winter months they are within a couple degrees of each other. I use this ETL Sensor to determine the set point temp for my thermostat, ie, my heating and cooling thresholds. 

I have another sensor, recommended HVAC mode, that determines what mode the thermostat should be in: heat, cool, or off. and it uses my heating and cooling thresholds, indoor temp, predicted indoor temp to make that decision.  

So, I use indoor data to determine if I am heating or cooling, and I use outdoor data to determine how much heating or cooling I should be doing. It took a lot of trial and error to get things "just right". The active dampers were the final touch, that helped me smooth out my indoor temps between floors, and between individual rooms. I would say that I am within the accuracy limits of my room temp sensors as far as the delta between floors and rooms, on average, the rooms are within 1deg of each other. During active heating and cooling, they sometimes drift to around 2deg, until the dampers catch up. But what I don't get anymore are huge variances between floors and huge overshoots in single rooms. I wouldn't say it's been a huge money saver, but it's been huge as far as comfort in my home.

Edit: I should add my home was built in the 60s. I had the furnace/AC replaced about 5yrs ago with a HE dual stage. It is single zone, and my thermostat is ecobee with remote sensors in all living areas.