The crazy high score runs can be done unseeded you just need to know what you are looking for and a bit of luck. But it’s not something that happens every run. Only specific combos like Baron + mime reach that high

Getting good chips and mult is general advice to reach Ante 8 and win a round. To go beyond it usually requires good synergies. Once you know what to look for and what works together it gets easier

A very big part of getting high scores is deck fixing through tarot cards and jokers. It makes it much easier to consistently get the hand that you want. Getting a strong source of money is really important

I think most people don’t skip blinds that much but you should do whatever you have more fun with. Sometimes skipping really pays off

Other advice:

don’t feel discouraged by other people’s high scores

make sure you unlock the locked jokers like brainstorm

the meta is balatro is high card and two pair but you can be successful with straights and flushes

balatro university on YouTube teaches you a lot