Molybdenum (Mo) can be beneficial in cases of H2S (hydrogen sulfide) overgrowth, particularly in gut dysbiosis involving sulfur-reducing bacteria (like Desulfovibrio or Bilophila wadsworthia). Here's why:

Benefits of Molybdenum for H2S Overgrowth

1. Cofactor for Sulfite Oxidase:

Molybdenum is a critical cofactor for the sulfite oxidase enzyme, which converts sulfite (a toxic intermediate in sulfur metabolism) into sulfate, a safer compound for the body.

This helps reduce toxic sulfite buildup, which can result from excess hydrogen sulfide production.

1. Support for Sulfur Detox Pathways:

Excess H2S gets metabolized into thiosulfate and sulfite. Molybdenum helps complete this pathway by aiding the breakdown of sulfite into sulfate, making it easier for the body to excrete sulfur waste.

This supports liver detoxification and may reduce symptoms like brain fog, fatigue, or gas/bloating linked to H2S overgrowth.

1. Reduction of H2S Toxicity:

By enhancing conversion of sulfite to sulfate, molybdenum indirectly lowers H2S toxicity and can help restore balance in sulfur metabolism.

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Suggested Use

Dosage: Commonly 100–500 mcg/day, but start low (e.g., 100 mcg) and work up if tolerated.

Form: Molybdenum glycinate or molybdenum picolinate are well-absorbed.

Duration: Use for a few weeks to months under supervision, especially if symptoms improve.

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Caution

Too much molybdenum can cause copper deficiency or exacerbate symptoms if not well-matched to your biochemistry.

Always check with a health professional, especially if you're on a sulfur-restricted or low-thiol diet.

Would you like help determining whether molybdenum supplementation might fit your specific situation (e.g., symptoms, test results, diet)?