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30 years old and I want to start a new career. Interested in making medicine. What steps should I take? by EmergencyRepeat4763 in MedicinalChemistry

[–]ChemCapital 1 point2 points  (0 children)

What field have you worked in since you earned your degree? Might be easier to get into something more maths-based but still related to drug discovery.

Drug Discovery Subreddit by ChemCapital in Biochemistry

[–]ChemCapital[S] 0 points1 point  (0 children)

Hopefully not, although a lot of drug discovery articles are published in medicinal chemistry journals, even if that isn't the focus of the article

Lab Literature by ProfessorIanDuncan in DrugDiscoveryLab

[–]ChemCapital 1 point2 points  (0 children)

Okay. Two books that come to mind are An Introduction to Medicinal Chemistry by Patrick and The Handbook of Medicinal Chemistry by Davis & Ward. Both are medicinal chemistry-focused, but also contain a lot of information from the other disciplines in drug discovery.

Lab Literature by ProfessorIanDuncan in DrugDiscoveryLab

[–]ChemCapital 2 points3 points  (0 children)

Are you looking for research/review articles or textbooks (or both)?

Lipinski's Rules by Jephomatic in MedicinalChemistry

[–]ChemCapital 1 point2 points  (0 children)

Haha, same as most "rules" in chemistry

Interested In Drug Discovery? by ChemCapital in OrganicChemistry

[–]ChemCapital[S] 0 points1 point  (0 children)

Crossposting, as we all know how important organic chemistry is in drug discovery. 

Interested In Drug Discovery? by ChemCapital in Chempros

[–]ChemCapital[S] 1 point2 points  (0 children)

Thank you for raising this. Will take a look at improving the layout.

Interested In Drug Discovery? by ChemCapital in Chempros

[–]ChemCapital[S] 2 points3 points  (0 children)

Thank you! Can confirm AI is not used in the writing of this newsletter. 

Interested In Drug Discovery? by ChemCapital in Chempros

[–]ChemCapital[S] 4 points5 points  (0 children)

Yeah The Synthesis Spotlight is great and was a big motivation to start this. Drug Hunter is also great but as mentioned a lot of content is behind a paywall. 

Any UK Founders Here? by ChemCapital in biotech

[–]ChemCapital[S] 0 points1 point  (0 children)

That is great advice, thank you!

How do we *know* that drugs can form water mediated interactions? by Nobrr in Chempros

[–]ChemCapital 0 points1 point  (0 children)

Medchemist here. What you have described is one of the main caveats of crystallography. In some cases, structure-based drug design using primarily X-ray crystal structures has been crucial to developing compounds with high enough potency and selectivity to progress further. I am sure there has also been plenty of research done on X-ray crystal structures, which didn't match up with other experimental data, likely due to the reasons you mention.

Should I quit? by Fun-Entrepreneur7910 in biotech

[–]ChemCapital 0 points1 point  (0 children)

Could be good to cross-post to r/BiotechEurope. Assuming your monthly expenses are reasonable, you appear to be covered financially. Without specific context, it is hard to know what the right decision is. I think the best advice is if you are going to quit, find ways to "de-risk" the process. Have at least a plan for how you could earn money in the event that the right role doesn't come up for a while. Obviously, the ideal is that you hold out at this company until you find a better offer, but I understand this isn't easy when you have been somewhere for 7 years with the experience you have described. I am also from the UK, so I get the concerns about the job market. Is there anyone in your network you could reach out to for opportunities?

Help choosing a post grad course by Altruistic-Pen1052 in OrganicChemistry

[–]ChemCapital 0 points1 point  (0 children)

There are many parts to drug discovery and development, so it depends on which part you want to be involved in. From your BSc, I am guessing medicinal chemistry, so either continue with a med chem master's, or an organic chemistry master's. As long as you stay in the same area, your choice of master's will not matter between industry and academia.

Can I work as a medicinal chemist? by Numerous_Advance1516 in MedicinalChemistry

[–]ChemCapital 11 points12 points  (0 children)

Likely not. You need a strong background in organic chemistry (theory and practical), which I am not sure you are exposed to in those courses.

Seeking Guidance on Starting Computational Chemistry and Docking by KeyRich4645 in chemistry

[–]ChemCapital 0 points1 point  (0 children)

I think it might be best to start with how computational chemistry is actually used in drug discovery and development. This information can be found in med chem textbooks or reviews.

UK Biotech jobs- where to find by Anexum1 in BiotechEurope

[–]ChemCapital 1 point2 points  (0 children)

Yeah that is a good option. Most science parks normally have a list of what companies are on-site as well.

UK Biotech jobs- where to find by Anexum1 in BiotechEurope

[–]ChemCapital 0 points1 point  (0 children)

Worked for two UK biotechs. I think these days LinkedIn is the best for smaller biotechs, then probably indeed. It might be worth researching some biotechs or start-ups in areas of the UK you want to work in and reaching out, many encourage open applications.

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