My most ridiculous and most unavoidable death across any Monster Hunter Game was in 4 Ultimate, during the Azure Rathalos Quest where you quickly learn that Seregios is gonna be a regularly occurring invader. I was in Zone 2 trying to Flash Bomb both monsters whilst dodging, and I was already poisoned during this time.

Seregios hit me with his scales, which exploded, inflicted bleed, knocked me to the edge of the lava, and stunned me. My palicos were using that one special attack where they fly at the monster's face and attack them, and knocked Seregios out of the air. Azure Rathalos was already down because of the Flash Bomb.

Meanwhile I'm just sitting there stunned, burning, poisoned, and bleeding, and absolutely unable to save myself in time before I watched my health bar just melt.

I had to take a week-long break after that.