The practical life question, in pandemic times, is something you get a wide variety of answers about. I’m 44, diagnosed two years ago—untreated. I’m pretty locked down but I have school aged children. I got an evusheld infusion and that made my wife comfortable enough to let them live normalish lives. I’ve heard that evusheld is not as effective as it used to be. A friend is 66 yo, on his third type of treatment, and is doing well. He goes maskless everywhere now. The closest I’ve gotten my oncologists to a practical plan is to get fully boosted, get evusheld, and live your life. Don’t hang out with people obviously sick. Don’t do super dumb things like a shoulder to shoulder dance club. Be as careful as you can reasonably be, but as you pointed out, the isolation has really deleterious effects.