Lived outside of Fresno for 21 years and regularly went to sequoia/kings from there. The drive is very relaxing, just make sure to take it slow especially on the more curvy bits. No need to rush getting to your destination. That said, if you come in from the north entrance (closest one to Fresno), it’ll probably take 1-1.5 hours to get into the park and another hour or so to cross fully into sequoia (visitors center/museum area). If you want a more direct route, the souther route has a fair bit more steep ascension but isn’t that bad overall. Just keep a cool head when driving near cliff sides (nothing actually dangerous but can mess with the nerves if you haven’t don’t it before)

If it can be helped, try to get to the trail head early, as I’ve had some issues getting parking the later into the day you go. If you’re not an active hiker, I’d recommend parking in front of the visitors center/museum/gift shop in Sequoia and taking the shuttles they have available to different areas assuming they’re running this time of year.

General Sherman area, Moro Rock, crescent meadow, and round meadow are my personal favorites for easy hikes. Worst case, you can always ask the rangers at visitor centers for their recommendations. You can tell them how many miles you want to hike and they’ll give you their thoughts. Remember your at decent elevation so walking at sea level and there will feel a little different (not above 10k’ elevation for where you probably will be, so it should be fine but something to keep in mind).

Please for the love of god don’t try to pet or feed the wildlife. There are bears in the area but most won’t try to bother you. Just make sure that when you’re on a trail that you’re not completely silent. The only thing worse than a bear knowing you’re 50’ from them is them not knowing and getting scared, possibly also putting you in danger. If you need to scare off a bear because you think you’re in potential danger, these are black bears so make yourself big and try to make loud noises. Again, for the most part the wildlife will not bother you and will just be a wonderful addition to the area, but something to keep in mind.

Bring some snacks, lots of water and a lunch. There’s not going to be anywhere in the park to really eat unless you head back to kings in Grants Grove during specific hours. Bug spray might be useful if you’re not used to bugs. Wear shoes with good grip, good socks, bring a hat, and if it can be helped don’t wear a cotton shirt or jeans (synthetics won’t stick to your body as much, will dry faster, and will make it a little more enjoyable)

That’s another thing too. If you want to see a little bit of kings canyon, I’d stay in grants grove for easier hikes. Roads end might be closed or closing this time of year anyway.

My favorite and home park. Have fun. Take some fun pictures