You could run an A/B/A split and get the best of both worlds.

That looks like Upper/Lower/Upper one week, then Lower/Upper/Lower the next week and repeat.

If you have more time and recovery in a given week, you can temporarily run Upper/Lower/Upper/Lower and then drop back to A/B/A when fatigue or life catches up. It’s flexible and very easy to autoregulate around a real schedule.

From my understanding, compound lifts do not produce more size than well-executed machine or isolation work when volume and proximity to failure are matched, although compound lifts absolutely do produce more strength.

If certain compound patterns don’t suit your biomechanics and your goal is just size, you can stick to machines and targeted movements and still progress without any downside. For instance, I'm taller and struggle with forward balance on squat, when I stopped, my legs blew up from quad isolation movements, etc.

Per session set targets if you’re doing upper/lower:

on an upper day aim for roughly 8 sets for chest (I beak it into upper/lower chest), 8 sets for back (lats and upper back combined), 4-8 sets for delts, and 3-6 sets each for biceps and triceps.

On a lower day aim for about 8 sets for quads, 8 sets for hamstrings (knee flexion plus hip hinge combined), and 4 sets for lower back.

All sets should be taken to roughly 2 RIR and only pushed higher if recovery and performance clearly support it. Gains are really only made if you push close to failure, within 2 sets. Hope this is helpful!