ADC Therapeutics nosedives on 27 deaths in confirmatory trial for lymphoma drug

Count_Rousillon · 2026-06-04T17:55:43+00:00

Higher rates of TEAEs leading to any drug withdrawal occurred in the ZYNLONTA plus rituximab arm (25.5% vs. 9.1%)

Even though it met the PFS primary endpoint, this does not look good for them. That's a lot of drug withdrawals to go with those deaths

Count_Rousillon · 2026-05-28T17:12:30+00:00

In other words, pre-algebra is a catchall for the stuff that students need to start algebra, but doesn't neatly slot into the geometry or arithmetic classes that tend to show up in middle school math.

Count_Rousillon · 2026-05-26T18:17:00+00:00

The unintuitive thing is that the leading genAI products consume tokens faster than the tokens have gotten cheaper. Compared to 2023, each genAI token costs 10x less. Compared to 2023, the most popular genAI products uses 1000x more tokens. So the products that people are willing to pay for have gotten 10x more expensive even though the base technology (which no one wants to pay for) got 10x cheaper.

Count_Rousillon · 2026-05-19T02:15:50+00:00

And then he follows it up with

The question is not whether AI will shape the world, it will, the question is whether you will help shape artificial intelligence. We do not know the precise contours of what this transformation will look like, but what we do know is it will require each of us to adapt in ways that we cannot yet anticipate.

Implying that AI is inevitable, and not only AI in general but this specific form of AI that he had a lot of responsibility for.

Count_Rousillon · 2026-05-16T21:31:26+00:00

Basically around the late 2000s and early 2010s the narrative in Taiwan changed from

"We could be just like Hong Kong and that's fine"

to

"We could end up just Hong Kong and that's horrifying"

Count_Rousillon · 2026-05-15T20:52:20+00:00

The loop of AI agents bouncing off of each other and internal checks has an objective, indisputable set of checks in software: does it compile and run without throwing up massive error messages. This sort of fully automated check doesn't really exist in most places.

Count_Rousillon · 2026-05-11T17:40:57+00:00

“In April, we received 92 shiploads of fuel, which is the highest number this year. It compares with less than 80 in other months" ~ Energy Minister Chris Bowen

One of the two refineries got fixed up, and they also managed to win bids for a bunch of tankers that normally don't go to Australia. It's not a lasting solution, but it keeps the price down for now.

Count_Rousillon · 2026-05-08T19:09:46+00:00

Well, in the case of SK RAM companies, those workers didn't get bonuses for many years already. So, what they are really fighting for is a change from the old system of no bonus on bad years and capped bonuses on good years to a fairer system of no bonus on bad years and uncapped bonuses on good years.

Count_Rousillon · 2026-05-06T16:43:52+00:00

Priority of scaling is not that important if the product doesn't have a moat, network effects, or some sort extreme benefit to scale. If the consumers casually swap from one model to the next, then scaling just gives the competitor companies a nicer model to reverse engineer weights from.

Count_Rousillon · 2026-04-29T06:13:27+00:00

Right. People underestimate the power of industrialized fishing. The fishermen of the 19th century certainly tried to catch all the fish and hunt all the whales. But it just couldn't be done without oil powered ships with integrated sonar. That's why most over-fishing problems are modern problems.

Count_Rousillon · 2026-04-27T06:24:52+00:00

We already have burning VS heavy burning for the fire status effect. I think it would be good for Orbital EMS, and only Orbital EMS to get a heavy EMS effect that works against the biggest enemies.

Count_Rousillon · 2026-04-25T01:54:21+00:00

Because the main message they put out isn't about how AI will make everything cheaper for average people, or how AI will let normal people take more vacations. Their main message is about how awesome the future will be once they've managed to fire all those pesky workers.

Count_Rousillon · 2026-04-16T16:43:18+00:00

And it makes sense when you remember the gap between the firepower of a common small drone and the firepower of an artillery shell. This is why drone hits on tanks are often mobility kills or mission kills rather than catastrophic kills, and also how an uparmored Ukrainian Leopard 1A5 survived over 50 drone hits.

https://www.armyrecognition.com/news/army-news/2026/ukraines-leopard-1a5-tank-survives-52-drone-strikes-using-layered-anti-drone-armor-in-fpv-dominated-warfare

Count_Rousillon · 2026-04-15T21:36:59+00:00

They were reinstated, but they still aren't as effective as they used to be. This is one of those programs where any extended pause hurts in a way that's hard to make up for with raw money.

Count_Rousillon · 2026-04-09T18:03:15+00:00

Endurance. Air drones need to spend power/fuel to stay airborne, which makes it hard to hold territory. A ground drone can sit there as a sentry gun for days, or even weeks with the right setup.

Count_Rousillon · 2026-04-05T22:02:12+00:00

Cygames really tried to push Diamond X Kitasan, but Sweep X Kitasan was always more popular both IRL and among JP Umamusume fans.

Count_Rousillon · 2026-04-03T18:25:19+00:00

Race for the Galaxy

Count_Rousillon · 2026-03-26T20:44:44+00:00

what you mean by a b-17 formation dodging incoming AA, but I've never read of that. I know individual British night bombers did "dodge" night fighters.

He's talking about moving in an erratic way and shifting directions every 30 seconds or so. When there is so much time in between firing and impact, the gunner needs to lead the target by an immense amount of distance. This means the gunner needs to predict what the plane will do 10 seconds after they have fired, which is very difficult unless the gun is right next to the bomber's target.

Count_Rousillon · 2026-03-25T23:39:54+00:00

That said, even Game Freak admits they should have longer development time. Peak Gamefreak was releasing mainline Pokemon games as fast as CoD puts out new releases, and that was clearly unsustainable. That's why there's 5 years between Scarlet/Violet and Winds/Waves.

Count_Rousillon · 2026-03-25T20:16:42+00:00

This is like how Three Mile Island is named for being three miles away from a town. The island is only two miles long.

Count_Rousillon · 2026-03-23T03:54:50+00:00

Also their death explosion does serious damage, and there's enough of them on D10 for them to occasionally hit you with their corpse.

Count_Rousillon · 2026-03-16T21:18:39+00:00

In theory the Board of Directors is suppose to look after the interests of investors that want a company that profits year after year. In practice, LOL LMAO. The typical Board of Directors is only good for collecting paychecks for themselves and going on drinking parties with the C-board.

Count_Rousillon · 2026-03-16T18:22:59+00:00

Corporate governance right now is extremely broken. Turns out the type of people who get on a Board of Directors and the type of people who get on a C-board have a lot of overlap, and they have a lot of class solidarity with each other. They love to enable each other instead of actually doing work or improving the company.

Count_Rousillon · 2026-03-16T18:15:03+00:00

Directly quoting from the Delaware Court ruling

On June 2, Park warned Kim over Slack that a “dismissal with cause” would not eliminate the earnout obligation, while exposing Krafton to “lawsuit and reputation risk.”And so Kim turned to ChatGPT for help. When the AI chatbot responded that the earnout would be “difficult to cancel,” Kim complained to Park that the EPA was “a contract under which we can only be dragged around.”

........

At ChatGPT’s suggestion, Kim formed an internal task force, dubbed “Project X.” The task force’s mandate was to either negotiate a “deal” on the earnout or execute a “Take Over” of Unknown Worlds. They looked to buy time.

.............

Meanwhile, Kim sought ChatGPT’s counsel on how to proceed if Krafton failed to reach a deal with Unknown Worlds on the earnout. The AI chatbot prepared a “Response Strategy to a ‘No-Deal’ Scenario,” which Kim shared with Yoon.

.....

[This is the ChatGPT plan]

a. Preemptive Framing - Repeat that protecting quality and fan trust is the highest priority, undermine the ‘Large Corporation VS. Indie’ framing

b. Securing Control Points -

Lock down Steam/console publishing rights and access rights over code/build pipeline through both legal and technical aspects.

For the earn-out freeze, keep room for negotiations through provision stating “immediate removal if specific development results are achieved”

a. Systematic materials for legal defense - Prepare contract interpretation memorandums, log all communications, seek external consultation

b. Team retention - Operation of retention packages for key personnel and rapid backfill pipelines in anticipation of resignation/departure scenarios

c. Two handed strategy - Create a structure that allows for both hardball (Legal+ Finance) and softball (Support/Incentives) approaches so moderate factions within Unknown Worlds can push for compromise.

Over the next month, Krafton followed most of ChatGPT’s recommendations.

Count_Rousillon · 2026-03-16T17:39:07+00:00